Immunohistochemical Markers Combined with Tumor Necrosis Factor α The Clinical Significance of miRNA-107 in the Diagnosis of Gastric Cancer
Pan Zhiyu1, Gao Longtan2, Wang Ning3
1. Pathology Department of Xinzheng Public People's Hospital,Xinzheng 451100,Henan; 2. Department of General Surgery,Henan Tianyou Integrated Traditional Chinese and Western Medicine Cancer Hospital,Xinzheng 451100,Henan; 3. Department of Pathology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan 450000,China
Abstract：Objective To analyze the combination of immunohistochemistry indicators and tumor necrosis factor α、 The clinical value of miRNA-107 in the diagnosis of gastric cancer. Method 48 gastric cancer patients（gastric cancer group）admitted to the hospital were included in the study.In addition,48 benign gastric cancer patients（benign gastric cancer group）and 48 healthy individuals（healthy group）who visited the hospital during the same period were selected.Immunohistochemical indicators and tumor necrosis factor tests were performed on all tested subjects- α And miRNA-107 testing.Subsequently,based on the degree of disease progression of gastric cancer patients,the gastric cancer group was divided into an early group（n=22）and an advanced group（n=26）.The immunohistochemical index test and tumor necrosis factor were compared between the two groups of patients- α Tumor crossing factor- α,TNF- α）And miRNA-107 test,receiver operating characteristic（ROC）analysis of immunohistochemical indicators,tumor necrosis factor- α And the diagnostic value of miRNA-107 test in gastric cancer disease. Result In the gastric cancer group,the human epidermal growth factor was regulated by -2（Her-2）and TNF- α、 MiRNA-107 was higher than the other two groups（P<0.05）.Compared with the early group,Her-2 and TNF in patients in the advanced group- α And miRNA-107 levels were higher,with significant differences（P<0.05）.Joint testing has the highest diagnostic value in the diagnosis,differential diagnosis of benign and malignant gastric cancer,and evaluation of gastric cancer progression.Its Area Under Curve（AUC）values are 0.949,0.997,and 1.000,respectively. Conclusion Her-2,TNF- α The increase in miRNA-107 levels is closely related to the severity of gastric cancer,and the combined detection of this indicator is of great significance in clarifying the diagnosis,malignancy,and progression of gastric cancer.
潘治宇, 高龙潭, 王宁. 免疫组化指标结合肿瘤坏死因子-α、miRNA-107在胃癌疾病诊断中的临床意义[J]. 哈尔滨医药, 2025, 45(1): 17-20.
Pan Zhiyu, Gao Longtan, Wang Ning. Immunohistochemical Markers Combined with Tumor Necrosis Factor α The Clinical Significance of miRNA-107 in the Diagnosis of Gastric Cancer. journal1, 2025, 45(1): 17-20.
2025, Vol. 45 
