Abstract：Objective To analyze the early treatment response and prognostic factors of children with acute lymphoblastic leukemia(ALL). Methods 80 cases of children with ALL in our hospital were selected as experimental subjects,and all the subjects were divided into 17 cases in the poor prognosis group(relapse or death)and 63 cases in the good prognosis group(no relapse or death)according to their prognosis.Sex,age,immunophenotyping(B-cell type,T-cell type),bone marrow morphology(M1,M2,M3),initial platelet count(PLT),fusion gene(negative,benign risk,poor risk),response to prednisone test(good response,poor response),and microscopic residual lesions(MRDs)on the 19th and 46th day of induction chemotherapy were collected in the 2 groups,and were compared.early treatment response of the 2 groups and analyze the factors influencing the prognosis of ALL. Results The incidence of poor prednisone test response and MRD positivity on the 46th d of induction chemotherapy were higher in the poor prognosis group than in the good prognosis group and(P<0.05);initial WBC,fusion gene,prednisone test response,and MRD on the 46th d of induction chemotherapy were the single factor affecting the prognosis of ALL(P<0.05);logistic regression analysis showed that initial WBC≥100×109/L,poor risk of fusion gene,poor response to prednisone test,and high MRD positivity on the 46th d of induction chemotherapy were risk factors affecting the poor prognosis of children with ALL(P<0.05). Conclusion Early treatment response can assess the prognostic outcome of children with The prognostic effect of ALL,and the high initial WBC and poor response to prednisone test are risk factors affecting the poor prognosis of children with ALL,and the clinic can take active preventive measures according to the relevant factors to improve the survival rate of children.
2025, Vol. 45 
