Abstract：Objective Effect of Nicorandil Combined with a Low Glycemic Index Diet on Fractional Flow Reserve in Hypertensive Patients with Left Ventricular Hypertrophy. Methods A total of 98 hypertensive patients with left ventricular hypertrophy treated at our hospital were randomly assigned to either the study group(n=49)receiving nicorandil plus low-GI diet intervention or the control group(n=49)receiving nicorandil alone.Outcomes included blood pressure control,therapeutic efficacy,LVH regression,fractional flow reserve(FFR),and adverse events. Result: Post-treatment,the study group demonstrated superior outcomes:lower systolic pressure(113.35±12.06mmHg vs control,P<0.05),higher diastolic pressure,and greater clinical efficacy(93.88% vs 79.59%,P<0.05).Significant LVH regression was observed through reduced LVEDD,IVST,LVPWT and LVMI(all P<0.05).The group also showed improved fractional flow reserve(0.95±0.07 vs control,P<0.05)with comparable low adverse event rates(P>0.05). Conclusion The combination of nicorandil with a low-GI diet significantly improves fractional flow reserve in hypertensive patients with LVH,demonstrating excellent safety.This combined therapy shows superior efficacy in reversing left ventricular hypertrophy and enhancing cardiac function,warranting clinical adoption.
2025, Vol. 45 
