Efficacy of Ulcer Decoction Combined With Rabeprazole in the Treatment of hp-Associated Duodenal Ulcer and Its Effect on Serum NF- B and TNF-in Patients
Li Jing
Department of Western Medicine,Nanyang First People's Hospital,Nanyang 473000 China
Abstract：Objective To investigate the efficacy of ulcer decoction combined with rabeprazole in the treatment of hp-associated duodenal ulcer and its effect on the serum Nuclear factor kappa-B（NF-B） and Tumor necrosis factor-（TNF-）.Methods According to the random number table method,96 cases of hpa-associated duodenal ulcer patients admitted to the department of gastroenterology of our hospital were divided into control group and observation group,48 cases each.The control group was treated with rabeprazole enteric-coated tablets combined with clarithromycin tablets and amoxicillin capsules,and the observation group was treated with ulcer decoction based on rabeprazole enteric-coated tablets combined with clarithromycin tablets and amoxicillin capsules.Serum levels of NF-B and TNF- were compared before and after treatment.Results the total clinical effective rate of the observation group was 93.75%,significantly higher than that of the control group（77.08%）（P< 0.05）.after treatment,the serum levels of TNF- and NF- B in both groups were significantly lower than those before treatment（P< 0.05）,and the serum levels of the above two indicators in the observation group were significantly lower than those in the control group（P<0.05）.the eradication rate of Hp in the observation group was 93.75%,significantly higher than that in the control group（72.92%）（P< 0.05）.The recurrence rate of the observation group was 10.42%,significantly lower than that of the control group（18.75%）（P< 0.05）.Conclusion Ulcer decoction combined with rabeprazole is effective in the treatment of hp-associated duodenal ulcer,which can effectively eradicate Hp,reduce the rate of disease recurrence,and reduce the serum levels of NF- B and TNF- in patients.
李晶. 溃疡汤联合雷贝拉唑治疗Hp相关性十二指肠溃疡的疗效及其对患者血清NF-κB 与TNF-α的影响[J]. 哈尔滨医药, 2021, 41(2): 43-44.
Li Jing. Efficacy of Ulcer Decoction Combined With Rabeprazole in the Treatment of hp-Associated Duodenal Ulcer and Its Effect on Serum NF- B and TNF-in Patients. journal1, 2021, 41(2): 43-44.
2021, Vol. 41 
