Effect of Hemoperfusion Combined With Penehyclidine Hydrochloride on Oxidative Stress in Patients With Severe Acute Organophosphorus Pesticide Poisoning
Wang Qiuju, Guo Huimin, Li Haiyan
Department of Pharmacy,Xichuan County People's Hospital,Nanyang 474450,China
Abstract：Objective To observe the effects of hemoperfusion combined with penehyclidine hydrochloride on oxidative stress in patients with severe acute organophosphorus pesticide poisoning. Methods A total of 60 patients with severe acute organophosphorus pesticide poisoning were selected.According to the random number table method,they were divided into hemoperfusion group and combined group,30 cases each.The hemoperfusion group received blood perfusion treatment,while the combination group was treated with penehyclidine hydrochloride on this basis.After treatment,the treatment effect,changes of cholinesterase,changes of stress indicators（SOD,LDH）were observed. Results The cure rate of the combined group was higher than that of the hemoperfusion group,and,the coma time,the total amount of clodidine,atropine,and the length of hospital stay were lower than the hemoperfusion group,the differences were statistically significant（P<0.05）.After treatment,the cholinesterase activity in the combination group was higher than that in the hemoperfusion group（P<0.05）,and the cholinesterase activity returned to normal time was shorter than the hemoperfusion group（P<0.05）.There were no significant differences in SOD,and LDH in the two groups before treatment（all P>0.05）.After treatment,the LDH in the combination group were all not significant.After treatment,and LDH in the combination group were lower than those in the hemoperfusion group（all P<0.05）,and SOD was higher than those in the hemoperfusion group（P<0.05）. Conclusion Hemoperfusion combined with penehyclidine hydrochloride in the treatment of severe acute organophosphorus pesticide poisoning has a significantly improved effect,and can improve the level of stress indicators with high safety.
王秋菊, 郭慧敏, 李海燕. 血液灌流联合盐酸戊乙奎醚对急性重度有机磷农药中毒患者氧化应激水平影响[J]. 哈尔滨医药, 2021, 41(5): 5-7.
Wang Qiuju, Guo Huimin, Li Haiyan. Effect of Hemoperfusion Combined With Penehyclidine Hydrochloride on Oxidative Stress in Patients With Severe Acute Organophosphorus Pesticide Poisoning. journal1, 2021, 41(5): 5-7.
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2021, Vol. 41 
