Research Progress of Mesenchymal Stem Cells in Scar Formation and Therapeutic Applications
Fan Yongmei1, Lv Kaiyang1, Zeng Yueqin2, Liu Wenjun1
1. Department of Burn Surgery,Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China; 2. Biomedical Engineering Research Center of Kunming Medical University,Kunming 650101,China
Abstract：Cicatrix is a series of damage and repair reactions in the damaged part after the body's skin tissue is subjected to trauma or burns and other adverse stresses，and finally ends in connective tissue repair，forming a tissue form that is not exactly the same as normal skin structure and function.Mesenchymal stem cells（MSCs）can secrete various growth factors，promote cell regeneration and repair，and can promote angiogenesis in cicatrix tissues and reduce local inflammation；degrade abnormally accumulated collagen and reshape cicatrix tissue；it has a two-way regulatory effect on the immune function of local tissues.Therefore，the application of MSCs in the prevention and treatment of cicatrix has broad application prospects.This article reviews the literature published in recent years，and reviews the research directions and clinical applications of MSCs on cicatrix tissue treatment mechanisms such as regeneration and healing，anti-inflammatory effects，anti-fibrosis effects，and immune regulation.
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2023, Vol. 43 
