耐碳青霉烯类铜绿假单胞菌血流感染耐药基因及毒力因子分析

doi:10.3969/j.issn.1001-8131.2023.04.014

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Abstract Objective To analyze the drug resistance genes and virulence factors of carbapenem-resistant pseudomonas aeruginosa（CR-PA）bloodstream infection（BSI）. Methods A total of 156 inpatients with pseudomonas aeruginosa（PA）BSI were selected as the research subjects,51 strains of CR-PA were obtained after culturing their blood,urine,sputum and other samples.The antibacterial drug susceptibility test results of CR-PA and the positive detection rate of drug resistance genes and virulence genes were analyzed. Results Among the 51 CR-PA strains,the antibacterial drugs with the resistance rate≥50% were cefepime , meropenem , amikacin,cotrimoxazole , gentamicin and imipenem from high to low. Antibacterial drugs with the resistance rate≥50% were piperacillin+tazobactampyocyanin, ciprofloxacin and ticarcillin from high to low. Among them,piperacillin+tazobactampyocyanin was the antibacterial drug with the lowest resistance rate and the highest drug sensitivity rate.Among the 51 strains of CR-PA,the positive rate of resistance gene ant（2''）-I（58.82%）and virulence gene plcH（100.00%）were the highest.And the drug resistance genes with a positive rate over 50.00% were aprA（98.04%）,exoS（92.16%）,algD（82.35%）,exoT（82.35%）,and exoU（68.63%）. Conclusions The drug resistance genes and virulence genes are widely distributed in CR-PA of BSI patients,and the clinical isolation rate of drug resistance gene ant（2''）-Ⅰ and virulence gene plcH is high.

Key words： bloodstream infection carbapenem resistant pseudomonas aeruginosa drug resistance gene virulence factor

Received: 18 August 2022

PACS:

R446.11

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	Articles by authors
	Liu Jing
	Han Jing
	Wu Xiaosha
	Ma Yuqin

Cite this article:

Liu Jing,Han Jing,Wu Xiaosha, et al. Analysis of Drug Resistance Genes and Virulence Factors of Carbapenem-resistant Pseudomonas Aeruginosa Bloodstream Infection[J]. journal1, 2023, 43(4): 41-43.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2023.04.014 OR http://www.hrbyybjb.org.cn/EN/Y2023/V43/I4/41

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