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| Predictive Value of Inflammatory Prognostic Index Combined with IL-11 for Immune Related Adverse Reactions in Advanced Non-small Cell Lung Cancer |
| Ma Hongwu, Wu Weixuan, Fan Haoqin, Chen Xueyan |
| Department of Oncology,Dafeng Hospital,Chaoyang District,Shantou 515154,China |
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Abstract Objective To investigate the predictive value of inflammatory prognostic index（IPI）combined with peripheral blood interleukin-11（IL-11）for immune-related adverse reactions（irAE）in advanced non-small cell lung cancer（NSCLC）.Methods The clinical data of 85 patients with NSCLC were retrospectively selected.According to the occurrence of irAE,the patients were divided into irAE group（n=26）and non-irAE group（n=59）.The clinical data of patients were collected.Multivariate logistic regression was used to analyze the relationship between IPI combined with IL-11 and irAE in NSCLC patients.ROC curve was further drawn to analyze the predictive value of IPI,IL-11 alone and combined detection for irAE in NSCLC patients.Results The levels of CRP,IL-6,IL-11,LDH,NLR,PLR and IPI in the two groups were significantly correlated（P<0.05）.Further analysis showed that IL-11,LDH and IPI were independent risk factors for irAE in NSCLC patients.ROC curve results showed that the area under the curve of IL-11 and IPI alone in predicting irAE in NSCLC patients was 0.731 and 0.786,respectively（P<0.05）.The area under the curve of the combined detection was the largest,which was 0.890（P< 0.05）.Conclusion IPI combined with IL-11 level is of great value in predicting irAE in NSCLC patients.
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Received: 21 November 2022
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2023, Vol. 43 
