矮小症患儿的临床特征及重组人生长激素联合来曲唑对p21waf/cip1、25-OH-D水平的影响

doi:10.3969/j.issn.1001-8131.2024.03.013

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Abstract Objective To investigate the clinical value of recombinant human growth hormone（RH GH）combined with letrozole in the treatment of idiopathic short stature（ISS）and its effect on the levels of p21waf/cip1 and 25 hydroxy Vitamin D（25-OH-D）in children. Methods 86 children with ISS were selected and randomly divided into control group and study group,43 cases each;The control group was given RH GH,and the study group was treated with letrozole for 12 months.Bone age,PINP,predicted lifetime height,p21waf/cip1,bone alkaline phosphatase（BALP）,25-OH-D,osteocalcin（OC）,clinical efficacy and adverse reactions were compared between the two groups. Results The excellent and good rate of curative effect in the study group（95.35% vs 76.74%）was higher than that in the control group（P<0.05）.Before treatment,there was no significant difference in bone age,PINP,predicted final height,BALP,OC,p21waf/cip1 protein,25-OH-D between the two groups（P>0.05）;After 12 months of treatment,the PINP,bone age,25-OH-D,OC and predicted final height of the study group were larger than those of the control group,and the p21waf/cip1 protein and BALP of the study group were smaller than those of the control group,with statistical significance（P<0.05）.There was no significant difference in the total adverse reaction rate between the two groups（11.63% vs 6.98%）（P>0.05）. Conclusion Combined with letrozole on the basis of RH GH has a good effect on ISS,which can effectively improve the bone metabolism index and 25-OH-D,p21waf/cip1 levels of children,promote the height growth and bone development of children,and improve the lifelong height value of patients.

Key words： Idiopathic short stature Recombinant human growth hormone p21waf/cip1 25 hydroxy Vitamin D Letrozole

Received: 26 June 2023

PACS:

R726.1

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	Guo Yongjing

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Guo Yongjing. Clinical Characteristics of Children with Short Stature and the Effect of Recombinant Human Growth Hormone Combined with Letrozole on p21waf/cip1,25-OH-D Levels[J]. journal1, 2024, 44(3): 38-41.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2024.03.013 OR http://www.hrbyybjb.org.cn/EN/Y2024/V44/I3/38

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