无创呼吸机联合抗生素降阶梯治疗急诊重症肺炎合并呼吸衰竭患者对呼吸功能的影响

doi:10.3969/j.issn.1001-8131.2025.02.001

Abstract
Figure/Table
References
Related Citation (5)

Download: PDF (441 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the clinical therapeutic value of using a ventilator combined with antibiotics to lower the ladder in the treatment of emergency severe pneumonia patients with respiratory failure.Method 80 patients diagnosed with emergency severe pneumonia complicated with respiratory failure were selected.The patients were randomLy divided into a control group and a study group,with 40 patients in each group,using a random number table method.The control group was given antibiotics to reduce the risk of respiratory failure,while the study group received non-invasive ventilators on top of the control group.The respiratory function of both groups of patients was analyzed,including dynamic lung compliance（Cdyn）,work of breathing（WOB）,oxygenation index（PaO₂/FiO₂）,heart rhythm,respiratory rate,and cardiac function,including left ventricular end diastolic diameter（LVEDD）,left ventricular ejection fraction（LVEF）,inflammatory factors such as C-reactive protein（CRP）,tumor necrosis factor（tumor necrosis factor）.Necrosis factor（TNF-α）,total adverse reaction rate,and overall efficacy rate.Result After treatment,Cdyn,WOB,PaO₂/FiO₂,and LVEF in both groups of patients were higher than before treatment（P<0.05）;Heart rate,respiratory rate,LVEDD,CRP,and TNF -αwere lower than before treatment（P<0.05）;The total adverse reaction rate of the research group was relatively low,and the total effective rate was relatively high（P<0.05）.Conclusion The combination of non-invasive ventilator and antibiotic ladder descent can effectively improve the respiratory function of emergency severe pneumonia patients with respiratory failure,and the overall effective rate is high,which is worthy of clinical promotion.

Key words： Non invasive ventilator Antibiotic ladder descent Emergency severe pneumonia with respiratory failure respiratory function

Received: 15 February 2025

PACS:

R563.8

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Wang Liwei
	Song Xiangkui
	Wan Zhenzhen

Cite this article:

Wang Liwei,Song Xiangkui,Wan Zhenzhen. The Impact of Non-invasive Ventilator Combined with Antibiotic Step-down Therapy on Respiratory Function in Emergency Severe Pneumonia Patients with Respiratory Failure[J]. journal1, 2025, 45(2): 1-3.

URL:

http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2025.02.001 OR http://www.hrbyybjb.org.cn/EN/Y2025/V45/I2/1

[1] 郝剑,贺杰,马俊帅,等.外周血CTLA4、TIM3对重症肺炎合并呼吸衰竭患儿疾病转归的预测价值[J].国际检验医学杂志,2023,44(22):2706-2709,2715.
[2] 谢波,高颖.经鼻高流量湿化氧疗联合肺泡灌洗治疗重症肺炎合并呼吸衰竭患者疗效观察[J].陕西医学杂志,2023,52(1):49-52.
[3] 韩希梅,方新友,陈云.无创呼吸机联合经鼻高流量氧疗序贯治疗对重症肺炎合并呼吸衰竭患者的治疗效果分析[J].世界复合医学,2023,9(9):63-66.
[4] 杨林林,徐新颖.无创呼吸机治疗小儿重症肺炎并发急性呼吸衰竭的临床效果[J].妇儿健康导刊,2023,2(12):69-71.
[5] 易欣,王华,吴柳春.无创呼吸机治疗的重症肺炎并发呼吸衰竭患者血清sTREM-1、SP-D、EVLWI水平变化及其临床意义[J].海南医学,2023,34(3):326-329.
[6] 中国研究型医院学会感染与炎症放射学专业委员会,中华医学会放射学分会传染病学组,中国科技产业化促进会数字健康专业委员会,等.甲型H1N1流感重症肺炎影像诊断中国专家共识[J].中华医学杂志,2023,103(33):2571-2578.
[7] 吴瑾. 雾化吸入布地奈德联合无创呼吸机治疗新生儿肺炎合并呼吸衰竭的临床研究[J].基层医学论坛,2023,27(29):72-74.
[8] 韩婷. 持续气道正压无创呼吸机治疗小儿重症肺炎并发急性呼吸衰竭的临床效果[J].妇儿健康导刊,2023,2(16):61-63,66.
[9] 陈耀武,陈一峰,白成剑,等.动态监测血清降钙素原水平在老年重症肺炎患者抗生素降阶梯治疗中的应用效果[J].广西医学,2023,45(3):355-357,361.
[10] 陈韵,张星星,高志凌,等.清金化痰汤加减辅助抗生素治疗老年重症肺炎疗效及对患者炎症反应递质的影响[J].陕西中医,2022,43(5):580-583.
[11] 徐秀娟,方长太,尤青海.血清转铁蛋白受体CD71水平对重症肺炎预后的预测价值[J].郑州大学学报(医学版),2023,58(4):529-532.
[12] 崔莹,金宇,刘晓玲,等.IL-6、TNF-α、D-D、NT-BNP在重症肺炎心肌损害患者中的检测及临床意义分析[J].标记免疫分析与临床,2023,30(4):589-593.
[13] 冷凌涵,陈浩,宋佳平,等.有创-无创序贯机械通气与传统有创机械通气治疗重症肺炎合并呼吸衰竭的疗效对比研究及院内死亡的危险因素分析[J].现代生物医学进展,2022,22(23):4576-4580,4559.
[14] 陈永生,付斌,郑永先,等.血清活化蛋白C及内皮素1和血管细胞黏附分子-1对老年重症肺炎合并呼吸衰竭患者病情进展及预后评估的价值[J].临床急诊杂志,2022,23(7):494-497,509.