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| Changes and Significance of Serum TGF beta 1,sIL-2R and Tumor Markers Before and After Radiotherapy in Patients With Hepatocellular Carcinoma |
| Wang, Jing |
| Zhengzhou Orthopedic Hospital,Zhengzhou 450001,China |
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Abstract Objective To investigate the changes and significance of serum transforming growth factor beta 1（TGF- beta 1）,interleukin-2 receptor（sIL-2R） and various serum tumor markers before and after radiotherapy in patients with primary liver cancer.Methods Selection of radiotherapy in our hospital of 90 patients with primary liver cancer（HCC group） and 90 cases of normal people were selected as control group,time of collection in March 2014~September 2016,liver cancer patients were treated by three-dimensional conformal radiation therapy,detection of TGF-before and after radiotherapy in patients with liver cancer group serum beta 1,sIL-2R,golgin 73（GP73）,alpha fetoprotein（AFP）,carcinoembryonic antigen（CEA） and compared with the control group,the subgroup analysis according to different clinical effects.Results Liver cancer group before and after treatment,the serum TGF-,sIL-2R,GP73 beta 1,AFP and CEA levels were significantly higher than the control group,the difference was statistically significant（P<0.05）;liver cancer patients 5 patients withdrew from the study,after treatment,liver TGF-serum beta 1,sIL-2R,GP73,AFP,the level of CEA before treatment were significantly decreased（P<0.05）;90 cases of liver cancer patients,5 cases achieved CR,PR in 52 patients,20 cases of SD patients,8 PD patients;before treatment,patients in group CR+PR and group SD+PD patients serum TGF- beta 1,sIL-2R,GP73,AFP,CEA the level of the difference was statistically significant（P>0.05）;after treatment,the patients in the CR+PR group serum TGF- beta 1,sIL-2R,GP73,AFP and CEA were significantly lower than in group SD+PD（P<0.05）.Conclusion The levels of serum TGF-,sIL-2R,GP73,AFP,and CEA in patients with primary liver cancer were significantly higher than those of patients with primary liver cancer,and were closely related to the effect of radiotherapy.
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Received: 30 June 2020
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2021, Vol. 41 
