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| The Effects of Different Types of Insulin on Blood Sugar Levels of Pregnant Women with Gestational Diabetes |
| Li Fei, Xu Xianghong, Qiu Chunxia, Hou Meilian* |
| Guangzhou Tianhe District Maternal and Child Health Hospital, Obstetrics Department, Guangzhou, Guangdong, 510000 |
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Abstract Objective To explore the changes in blood sugar levels of pregnant women with gestational diabetes mellitus after treatment with various types of insulin(including biosynthetic human insulin and aspart insulin). Methods Using the lottery method,62 pregnant women with gestational diabetes who were hospitalized at Guangzhou Tianhe District Maternal and Child Health Hospital from January 2021 to December 2025 were randomly divided into the control group(treated with biosynthetic human insulin,n=31) and the study group(treated with insulin aspart,n=31).The changes in the effects of the two groups,blood glucose-related indicators,the cycle of achieving blood glucose control,lipid metabolism levels,and adverse maternal and infant outcomes were evaluated. Results The overall clinical effective rates of the two groups showed a significant difference(P<0.05);compared with before treatment,the blood glucose-related indicators [fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),2-hour postprandial blood glucose(2hPG)]and lipid metabolism indicators [triglycerides(TG),total cholesterol(TC)]of the two groups after treatment were significantly decreased,and the decrease in the study group was better than that in the control group(P<0.05);while the levels of high-density lipoprotein cholesterol(HDL-C) in both groups showed an increase,and the increase level in the study group was significantly higher than that in the control group(P<0.05);the time for all indicators of FPG,2hPG,FPG and 2hPG to reach the standard in the study group was shorter than that in the control group(P<0.05);the incidence of adverse neonatal outcomes and adverse pregnancy outcomes in the study group was lower than that in the control group(P<0.05). Conclusion Compared with the use of biosynthetic human insulin,the aspart insulin treatment regimen is more effective for pregnant women with gestational diabetes.It demonstrates significant advantages in improving blood sugar control,regulating lipid metabolism,shortening the period to achieve blood sugar control,and improving the prognosis of both mothers and infants.
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Received: 01 April 2026
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2026, Vol. 46 
