|
|
|
| Distribution of Pathogens and Laboratory Analysis in Patients With Chronic Obstructive Pulmonary Disease Combined With Ventilator-Associated Pneumonia |
| Li Ning |
| Zhengzhou Sixth People's Hospital,Zhengzhou 450000,China |
|
|
|
|
Abstract Objective To investigate the distribution of pathogens and laboratory indicators in patients with chronic obstructive pulmonary disease（COPD）combined with ventilator-associated pneumonia（VAP）.Methods 118 patients with COPD and VAP,50 mechanically ventilated COPD patients without infection and 30 healthy physical examination patients were chosen in the study.All patients underwent bacterial culture and drug susceptibility testing and the analysis was implemented.Results There were 125 gram-negative bacteria,they were mainly on Acinetobacter baumannii,Pseudomonas aeruginosa,Klebsiella pneumoniae;There were 31 gram-positive bacteria,they were mainly on Staphylococcus aureus;Among Gram-negative bacteria,Acinetobacter baumannii,Pseudomonas aeruginosa,Klebsiella pneumoniae showed high resistance to ceftriaxone,aztreonam,ciprofloxacin,levofloxacin,etc.No imipenem and meropenem resistant bacteria were detected in the three gram-negative bacteria.Among Gram-positive bacteria,Staphylococcus aureus has high resistance to ciprofloxacin,erythromycin and penicillin.The levels of serum C-reactive protein（CRP）,interleukin-6（IL-6）and tumor necrosis factor（TNF-α）in the COPD with VAP group were significantly higher than those in the COPD group and the control group,and the difference was statistically significant（P<0.05）.The area under the curve for the diagnosis of COPD with VAP by serum CRP,IL-6 and TNF-α levels is 0.645,0.712,0.689.Conclusion The infection of patients with COPD and VAP is mainly on Gram-negative infection.Drug resistance to various drugs of the pathogenic bacteria in patients with infection.
|
|
Received: 14 January 2021
|
|
|
|
|
|
[1] 李静,刘政,马姣.慢性阻塞性肺疾病表型的研究进展[J].国际呼吸杂志,2016,36(19):1507-1511.
[2] 李淑媛,盖鑫,张建,等.ICU机械通气患者呼吸机相关性肺炎危险因素与干预措施[J].中华医院感染学杂志,2016,26(1):76-78.
[3] 李福琴,杨阳,张梦华,等.ICU呼吸机相关性肺炎患者病原菌分布与耐药性分析[J].中华医院感染学杂志,2016,26(11):2497-2499.
[4] 姚婉贞. 慢性阻塞性肺疾病诊治指南修改的说明与思考[J].中华结核和呼吸杂志,2013,36(4):243-245.
[5] 朱仕超,尹维佳,宗志勇,等.呼吸机相关性肺炎定义和判断标准研究进展[J].中华医院感染学杂志,2016,26(23):5517-5520.
[6] 董宏艳,冉素平,贾莉萍.住院患者多重耐药菌监测状况分析[J].临床肺科杂志,2016,21(10):1884-1886.
[7] 杜煦. 我院老年患者呼吸机相关性肺炎病原菌分布及药敏分析[J].临床肺科杂志,2013,18(5):840-842.
[8] 张萍,邢琳琳,阮昕,等.慢性阻塞性肺疾病患者呼吸机相关肺部感染的临床研究[J].中华医院感染学杂志,2017,27(22):5076-5078.
[9] 任占凤,班玛措,李静,等.重症监护室呼吸机相关肺炎患者的病原菌特征与耐药性及相关因素分析[J].中华医院感染学杂志,2017,27(23):5325-5328.
[10] 谢朝云,熊芸,孙静,等.慢性阻塞性肺疾病多重耐药菌感染的危险因素分析[J].天津医药,2016,44(6):744-747. |
| [1] |
. [J]. journal1, 2022, 42(2): 111-112. |
| [2] |
. [J]. journal1, 2022, 42(2): 130-131. |
| [3] |
Zhao Shuai. Clinical Effect of Invasive-Noninvasive Sequential Mechanical Ventilation on Patients With Severe Chronic Obstructive Pulmonary Disease and Respiratory Failure[J]. journal1, 2021, 41(6): 6-8. |
| [4] |
. [J]. journal1, 2021, 41(4): 40-41. |
| [5] |
. [J]. journal1, 2021, 41(2): 123-124. |
| [6] |
Wang Yijin, Qin Guoping, Xu Jiashun. To Explore the Clinical Value of Acetylcysteine Combined with Ambroxol in the Treatment of Acute Episode of Chronic Obstructive Pulmonary Disease in the Elderly[J]. journal1, 2021, 41(1): 27-28. |
|
|
|
|
2022, Vol. 42 
