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| Efficacy and Safety Analysis of Propylthiouracil in the Treatment of Hyperthyroidism |
| Jiao Dongan, Feng Mingjie, Zhou Hui, Li Junming |
| Pharmacy Department,The Second People's Hospital of Guangdong Province,Guangzhou 510317,China |
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Abstract Objective To investigate the efficacy and safety of propanthiouracil in the treatment of hyperthyroidism. Methods A total of 120 patients with hyperthyroidism who were admitted to the outpatient department of endocrinology or hospitalized in the ward of endocrinology department were collected and randomly divided into study group and control group,60 patients in each group.Methimazole was added to the control group and propyl thiouracil was added to the study group.The treatment effect,thyroid function related indexes and adverse drug reactions were compared between the two groups. Results The hypermetabolism-related symptoms and signs of hyperthyroidism patients were significantly improved after treatment with propylthiouracil,and the probability of symptom reduction was significantly higher than that of control group.In addition,serum FT3,FT4,TPOAb and TgAb in observation group were against control group,while TSH was higher than control group（P<0.05）.A total of 3 patients in the observation group had gastrointestinal adverse reactions during medication,which improved spontaneously after drug withdrawal,and the incidence of adverse reactions was significantly lower than that in the control group（P<0.05）. Conclusion For patients with hyperthyroidism,the application of propylthiouracil in the treatment of clinical effect is good,the symptoms of hypermetabolism are significantly reduced,but also significantly improve the thyroid function,less adverse reactions,high safety,is the preferred drug for the treatment of hyperthyroidism.
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Received: 28 July 2021
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2022, Vol. 42 
