间充质干细胞在瘢痕形成及治疗应用中的研究进展

doi:10.3969/j.issn.1001-8131.2023.01.051

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Abstract Cicatrix is a series of damage and repair reactions in the damaged part after the body's skin tissue is subjected to trauma or burns and other adverse stresses，and finally ends in connective tissue repair，forming a tissue form that is not exactly the same as normal skin structure and function.Mesenchymal stem cells（MSCs）can secrete various growth factors，promote cell regeneration and repair，and can promote angiogenesis in cicatrix tissues and reduce local inflammation；degrade abnormally accumulated collagen and reshape cicatrix tissue；it has a two-way regulatory effect on the immune function of local tissues.Therefore，the application of MSCs in the prevention and treatment of cicatrix has broad application prospects.This article reviews the literature published in recent years，and reviews the research directions and clinical applications of MSCs on cicatrix tissue treatment mechanisms such as regeneration and healing，anti-inflammatory effects，anti-fibrosis effects，and immune regulation.

Key words： Mesenchymal stem cells Scar formation Therapeutic application

Received: 11 December 2021

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R622

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	Articles by authors
	Fan Yongmei
	Lv Kaiyang
	Zeng Yueqin
	Liu Wenjun

Cite this article:

Fan Yongmei,Lv Kaiyang,Zeng Yueqin, et al. Research Progress of Mesenchymal Stem Cells in Scar Formation and Therapeutic Applications[J]. journal1, 2023, 43(1): 128-131.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2023.01.051 OR http://www.hrbyybjb.org.cn/EN/Y2023/V43/I1/128

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