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| The Expression of ING4 and Hypoxia-inducibleFactor-1 α in Cervical Lesions and Its Relationship with HR-HPV Infection |
| Hu Lijuan |
| Laboratory Department,Zhengzhou First People's Hospital,Zhengzhou 450001,China |
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Abstract Objective To analyze the expression of growth family member 4 （ING4） and hypoxia-inducible factor-1α （HIF-1α） in cervical lesions, and its relationship with high-risk HPV （HR-HPV） infection.Methods 25 cervical cancer tissuesamples（cervical cancer group）,50 cervical intraepithelial neoplasia（CIN）tissue samples（CIN1 group,CIN2-3 group）and 20 normal cervical tissue samples（normal group）were collected.HR-HPV was detected before surgery.The protein expression levels and correlation of ING4 and HIF-1α in each group,and their relationship with pathological parameters were analyzed.Results The HR-HPV infection rate was higher incervical cancer group,CIN1 group and CIN2-3 group than in the normal group（P<0.05）.The ING4 positive rate was the highest,and the HIF-1α positive rate was the lowest in the normal group.The HIF-1α positive rate was the highest in the cervical cancer group（P<0.05）.In HR-HPV infected tissues,the ING4 positive rate was the lowest,and the HIF-1α positive rate was the highest in the cervical cancer group（P<0.05）.There was a negative correlation between ING4 and HIF-1α levels in HR-HPV infected cervical cancer and CIN2-3 tissues（P<0.05）.Age,lymph node metastasis,vascular invasion,and the depth of myometrial invasion were independent risk factors for ING4 negative and HIF-1α positive inpatients infected with HR-HPV（P<0.05）.Conclusion The low expression of ING4 and high expression of HIF-1a in HR-HPV infected cervical lesions inhibit the proliferation and migration of vascular endothelial cells,thereby delaying the progression of cervical lesions.
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Received: 08 July 2022
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2023, Vol. 43 
