|
|
|
| The Value of Torasemide Combined With GIK In The Treatment of Intracranial Hypertension Caused by Severe Craniocerebral Trauma |
| Zhang Ming, Shang Yun, Wang Yangming |
| Emergency Department,First People's Hospital of Xinxiang City,Xinxiang 453000,Henan,China |
|
|
|
|
Abstract Objective To observe the value of torasemide combined with GIK in the treatment of intracranial hypertension caused by severe craniocerebral trauma. Methods The clinical data of 142 patients with intracranial hypertension caused by severe craniocerebral trauma treated were retrospectively analyzed,and they were divided into control group and observation group according to the medication regimen.67 cases in the control group were treated with torasemide;75 cases in the observation group were treated with torasemide combined with GIK.The GOS scores of the two groups after treatment were compared.The intracranial pressure（ICP）before treatment,30min,1h and 2h after treatment were compared.The levels of CVP,MAP,CPP and oxidative stress indexes（T-AOC,SOD,MDA）were compared between the two groups before and after treatment.The incidence of adverse drug reactions after treatment was compared between the two groups. Results After treatment,the GOS score of the observation group was significantly higher than that of the control group（P<0.05）.ICP decreased significantly in both groups,and the observation group was significantly lower than the control group（P<0.05）.The MDA level of the two groups decreased significantly,and the observation group was higher than that of the control group（P<0.05）.The levels of CVP,CPP,T-AOC and SOD were significantly increased in both groups,and the observation group was significantly higher than the control group（P<0.05）.There was no significant difference in MAP level and the incidence of adverse drug reactions between the two groups before and after treatment（P>0.05）. Conclusions Torasemide combined with GIK is effective in the treatment of intracranial hypertension caused by severe craniocerebral trauma.It can effectively control the symptoms of intracranial hypertension,reduce oxidative stress,and improve the prognosis of patients.It has high popularization and application value.
|
|
Received: 09 August 2022
|
|
|
|
|
|
[1] 杨昌立,王铁峰,崔海随,等.重型颅脑损伤患者术后并发脑梗死临床分析[J].中国实用神经疾病杂志,2021,24(2):118-124.
[2] 霍生杰,张文岐,刘金道,等.渗剂量7.5%高渗盐水和20%甘露醇降低颅内压的效果比较[J].中国医药导报,2019,16(26):141-144.
[3] 王子涵,黄力,姜红,等.静脉袢利尿剂不同使用方式对急性失代偿心力衰竭病人肾功能的影响[J].中西医结合心脑血管病杂志,2021,19(15):2623-2627.
[4] 程永寿,黄先辉.不同格拉斯哥昏迷评分颅脑外伤患者血清胰岛素生长因子Ⅱ、C型利钠多肽水平及预后研究[J].创伤与急危重病医学,2019,7(04):227-229.
[5] 柳兴军,王雷波,陈子祥.依据有创颅内压监测实施降颅压治疗的重型脑损伤患者预后观察[J].山东医药,2015,55(07):80-81.
[6] 陈天喜,姜岱山,王伶俐,等.不同评分方法对急性创伤性脑损伤患者早期死亡风险的预测价值[J].中华创伤杂志,2022,38(05):407-412.
[7] 宋梦娇,张磊,周美辉,等.3%高渗盐水和20%甘露醇治疗重型颅脑损伤合并颅内高压的临床比较观察[J].河北医学,2020,26(7):1170-1174.
[8] 吉其舰,彭海丽,郭小敏.重度颅脑外伤患者术后监测颅内压及压力相关指数的临床价值[J].临床急诊杂志,2021,22(5):335-339.
[9] 唐文华,张瑜,黄晓明,等.托拉塞米注射液联合软通道穿刺引流术对基底核区中等量脑出血患者的疗效[J].神经损伤与功能重建,2020,15(3):165-167.
[10] 史冬,赵建玉,李玺.硫辛酸对急性脑梗死患者SOD MMP-9及T-AOC的影响[J].中国实用神经疾病杂志,2017,20(1):101-103. |
| [1] |
Dou Jingjing, Zhang Yan, Wang Jiaoping. Study on Pulmonary Infection in 150 Patients With Severe Craniocerebral Injury in ICU Based on Logistic Regression Analysis[J]. journal1, 2022, 42(6): 7-8. |
| [2] |
. [J]. journal1, 2022, 42(5): 56-57. |
| [3] |
. [J]. journal1, 2022, 42(4): 80-81. |
| [4] |
. [J]. journal1, 2021, 41(4): 62-63. |
|
|
|
|
2023, Vol. 43 
