小剂量盐酸多奈哌齐联合盐酸美金刚治疗对阿尔茨海默病患者认知功能的影响

doi:10.3969/j.issn.1001-8131.2024.01.005

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摘要目的分析盐酸多奈哌齐联合盐酸美金刚对阿尔茨海默病（Alzheimer's disease,AD）患者认知功能的影响。方法选取AD患者86例,随机分为实验组和常规组,各组43例。常规组予以小剂量盐酸多奈哌齐,实验组在常规组基础上联合盐酸美金刚。对比两组疗效、阿尔茨海默病行为病理学量表（BEHAVE-AD）评分、阿尔茨海默病评价量表（ADAS-cog）、简易精神状态评价量表（MMSE）、炎性因子[白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）]水平及不良反应发生率。结果实验组总有效率93.02%（40/43）较常规组72.09%（31/43）高（P<0.05）;治疗后,实验组BEHAVE-AD评分较常规组低（P<0.05）;治疗后,实验组ADAS-cog评分较常规组低,MMSE评分较常规组高（P<0.05）;治疗后,实验组IL-6、TNF-α、CRP水平较常规组低（P<0.05）;实验组不良反应发生率6.98%（3/43）较常规组11.63%（5/43）对比差异无统计学意义（P>0.05）。结论对AD患者予以盐酸多奈哌齐联合盐酸美金刚效果显著,能改善临床症状、认知功能、精神状态,减轻炎症反应,且具有安全性。

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	刘凡
	刘晓鹏
	周玉

关键词 ：阿尔茨海默病, 盐酸多奈哌齐, 盐酸美金刚

Abstract：Objective To analyze the effects of donepezil hydrochloride combined with memantine hydrochloride on cognitive function in patients with Alzheimer's disease（AD）. Methods 86 cases of patients with AD were selected,and all of them were randomly divided into an experimental group and a conventional group,with 43 patients in each group.The conventional group was given low-dose donepezil hydrochloride,and the experimental group was combined with memantine hydrochloride on the basis of the conventional group.The curative effect,the Alzheimer's disease behavioralpathology scale（BEHAVE-AD）score,the Alzheimer's Disease Assessment Scale（ADAS-cog）,Mini Mental State Assessment Scale（MMSE）,the inflammatory factors [interleukin-6（IL-6）,tumor necrosis factor-α（TNF-α）,C-reactive protein（CRP）] levels and the occurrence rate of adverse reactionsof the two groups were compared. Results The total effective rate 93.02%（40/43）of the experimental group washigher than 72.09%（31/43）of the conventional group（P<0.05）;After treatment,the BEHAVE-AD score of the experimental group was lower than that of the conventional group（P<0.05）;After treatment,the ADAS-cog score of the experimental group was lower than that of the conventional group,while the MMSE score was higher than that of the conventional group（P<0.05）;After treatment,the levels of IL-6,TNF-α and CRP in the experimental groupwereall respectivelylower than thosein the conventional group（P<0.05）;The occurrence rate of adverse reactions of the experimental group was 6.98%（3/43）,which was not significantly different from that of the conventional group11.63%（5/43）（P>0.05）. Conclusion The combination of donepezil hydrochloride and memantine hydrochloride for AD patientshas a significant effect,which can improve the clinical symptoms,cognitive function and mental state,alleviate the inflammatory reactions,and has the safety.

Key words： Alzheimer's disease Donepezil hydrochloride Memantine hydrochloride

收稿日期: 2023-03-03

PACS:

R749.05

引用本文:

刘凡, 刘晓鹏, 周玉. 小剂量盐酸多奈哌齐联合盐酸美金刚治疗对阿尔茨海默病患者认知功能的影响[J]. 哈尔滨医药, 2024, 44(1): 17-19.
Liu Fan, Liu Xiaopeng, Zhou Yu. Effects of Low-dose Donepezil Hydrochloride Combined with Memantine Hydrochloride on Cognitive Function in Patients with Alzheimer’s Disease. journal1, 2024, 44(1): 17-19.

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http://www.hrbyybjb.org.cn/CN/10.3969/j.issn.1001-8131.2024.01.005 或 http://www.hrbyybjb.org.cn/CN/Y2024/V44/I1/17

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