A Mendelian Randomization Analysis on the Causal Associations between Lipids and Diabetic Retinopathy
Wang Xin1, Liu Xinghai2
1. Grade 2021 of School of Medical Imaging, 2. Institute of Basic Medicine and Forensic Medicine,North Sichuan Medical College,NanChong 637000,SiChuan,China
Abstract：Objective To investigate the bidirectional causal relationship between lipid and diabetic retinopathy（DR）.Methods Data of genome-wide association study on lipid and DR were collected.The bidirectional Mendelian randomization（MR）of two samples was performed by inverse variance weighted method,MR-Egger regression method and weighted median method.Cochran's Q test was used to check the heterogeneity of the results and the MR-Egger regression method to evaluate of the results.Results The results of inverse variance weighted method showed that phosphatidylethanolamine（16：0_18：2）（OR=0.916,95%CI：0.864~0.971,P=0.003,PFDR=0.174）and triacylglycerol 50：2（OR=0.850,95%CI：0.760~0.952,P=0.005,PFDR=0.174）decreased the risk of DR.The results of reverse MR analysis showed that DR was causally associated with increased diglycerol（16：0_18：2）（OR=1.064,95%CI：1.021~1.109,P=0.003,PFDR=0.194）and triacylglycerol 50：1（OR=1.067,95%CI：1.026~1.109,P=0.001,PFDR=0.194）.The results of various MR methods were basically consistent,and the results of sensitivity analysis showed that the above results were consistent and reliable.Conclusion Phosphatidylethanolamine（16：0_18：2）and triacylglycerol 50：2 have negative causal associations with the risk of DR,while DR has positive causal effects on diglycerol（16：0_18：2）and triacylglycerol 50：1.
王鑫, 刘行海. 脂质与糖尿病视网膜病变因果关系的孟德尔随机化分析[J]. 哈尔滨医药, 2024, 44(4): 37-40.
Wang Xin, Liu Xinghai. A Mendelian Randomization Analysis on the Causal Associations between Lipids and Diabetic Retinopathy. journal1, 2024, 44(4): 37-40.
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2024, Vol. 44 
