甘麦芪仙磁石汤结合常规安眠药物对老年心脾两虚型慢性失眠患者的临床疗效以及作用机制研究

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摘要目的探讨甘麦芪仙磁石汤结合常规安眠药物对老年心脾两虚型慢性失眠患者的临床疗效以及作用机制。方法选取中医门诊就诊的64例中医辩证为心脾两虚型的老年性失眠患者作为研究对象,按随机数表法分为观察组和对照组(各32例)。对照组给予常规安眠药物治疗,观察组在对照组的基础上给予甘麦芪仙磁石汤治疗,对比两组患者的临床疗效及中医症候评分、治疗前后的去甲肾上腺素(NE)及5-羟色胺(5-HT)水平、睡眠质量。结果观察组患者临床疗效总有效率高于对照组(93.75%vs .75.00%,P<0.05)、中医症候疗效总有效率高于对照组(93.75%vs .71.88%,P<0.05);治疗后两组患者的NE水平下降而5-HT水平上升(P<0.05),两组睡眠质量均有所改善(P<0.05),且观察组上述改善情况均优于对照组(P<0.05)。结论甘麦芪仙磁石汤结合常规安眠药物治疗可有效改善老年心脾两虚型慢性失眠患者的临床症状,疗效较单用常规安眠药物治疗明显,其作用机制可能是通过影响脑内5-HT、NE的含量而作用于睡眠-觉醒周期。

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	咸志强
	庄坤
	温楠楠

关键词 ：慢性失眠, 甘麦芪仙磁石汤, 心脾两虚型, 临床疗效, 作用机制

Abstract：Objective To explore the clinical efficacy and mechanism of Ganmai Qixian Magnetic Stone Decoction combined with conventional sleeping drugs in elderly patients with chronic insomnia due to heart and spleen deficiency.Methods From September 2018 to December 2019,64 elderly patients with senile insomnia who were dialectic of TCM and Spleen Deficiency were selected as the research subjects,and were divided into observation group and control group according to the random number table method.(32 cases each).The control group was given conventional sleeping medication,and the observation group was given Ganmai Qixian Magnet Decoction on the basis of the control group.The clinical efficacy and TCM symptom scores,norepinephrine(NE)and 5- Serotonin(5-HT)levels,sleep quality.Results The total effective rate of clinical efficacy in the observation group was higher than that in the control group(93.75% vs 75.00%,P<0.05),and the total effective rate of TCM symptoms was higher than the control group(93.75% vs 71.88%,P<0.05);after treatment The NE level decreased and 5-HT level increased in both groups(P<0.05).The sleep quality in both groups was improved(P<0.05),and the improvement in the observation group was better than that in the control group(P<0.05).Conclusion Ganmaiqixian Magnetic Stone Decoction combined with conventional sleep medicine can effectively improve the clinical symptoms of elderly patients with chronic insomnia with heart and spleen deficiency.The effect is more obvious than that of conventional sleep medicine alone,and its mechanism may be through affecting the brain 5- The contents of HT and NE act on the sleep-wake cycle.

Key words： Chronic insomnia Ganmai Qixian Cishi Decoction Heart and spleen deficiency type Clinical efficacy Mechanism of action

收稿日期: 2020-07-29

PACS:

R256.23

引用本文:

咸志强, 庄坤, 温楠楠. 甘麦芪仙磁石汤结合常规安眠药物对老年心脾两虚型慢性失眠患者的临床疗效以及作用机制研究[J]. 哈尔滨医药, 2021, 41(3): 123-125.
Xian Zhiqiang, Zhuang Kun, Wen Nannan. Study on Clinical Effect and Mechanism of Ganmaiqixian Magnetic Stone Decoction Combined with Conventional Sleeping Medicine on Elderly Patients with Chronic Insomnia. journal1, 2021, 41(3): 123-125.

链接本文:

http://www.hrbyybjb.org.cn/CN/ 或 http://www.hrbyybjb.org.cn/CN/Y2021/V41/I3/123

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