Abstract：Objective To investigate the correlation between serum levels of cathepsin S,angiopoietin-like protein 3（ANGPTL3）and anti-apoptotic polypeptide（HN）and their predictive value in patients with coronary heart disease and the severity of the disease.Methods A total of 126 patients with coronary heart disease who underwent percutaneous coronary intervention（PCI）were selected as the study group,and were divided into 45 cases of single lesions,42 cases of double lesions,and 39 cases of multiple lesions according to the number of lesions,and 42 patients with healthy examination in the same period were selected as the control group.The serum levels of cathepsin S,ANGPTL3 and HN were compared between the two groups.The serum levels of cathepsin S,ANGPTL3,HN and Gensini score were compared in the study group.The correlation between serum levels of cathepsin S,ANGPTL3 and HN and the number of lesions and Gensini score was analyzed.According to the prognosis of the study group within 6 months after treatment,the patients with poor prognosis and those with good prognosis were divided,and the serum levels of cathepsin S,ANGPTL3 and HN were compared.Multivariate logistic regression was used to analyze the influencing factors of poor prognosis,and receiver operating characteristic curve（ROC）was used to analyze the predictive value of individual and combined serum indexes for poor prognosis.Results The serum levels of cathepsin S and ANGPTL3 in the study group were higher than those in the control group,and the levels of HN were lower than those in the control group（P<0.05 ANGPTL3<ANGPTL3）.On the contrary,HN（P<0.05）,the serum levels of cathepsin S and ANGPTL3 in patients with poor prognosis were higher than those with good prognosis at 1 month after treatment,and the levels of HN were lower than those with good prognosis（P<0.05 ANGPTL3）.LVEF and serum HN level at 1 month after treatment were independent protective factors for poor prognosis（P<0.05）,and the AUC of cathepsin S,ANGPTL3 and HN was greater than that predicted by individual indicators（P<0.05）.Conclusion The serum levels of cathepsin S and ANGPTL3 are increased,while the serum HN level is decreased,which is closely related to the severity and prognosis of the disease.
李俊峰, 杨森, 高强. 血清cathepsin S、ANGPTL3、HN水平与冠心病患者病情程度及预后的相关性分析[J]. 哈尔滨医药, 2024, 44(4): 44-47.
Li Junfeng, Yang Sen, Gao Qiang. Correlation analysis of serum cathepsin S,ANGPTL3 and HN levels with the severity and prognosis of patients with coronary heart disease. journal1, 2024, 44(4): 44-47.
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2024, Vol. 44 
