Analysis of the Effect of GTR Combined with Fixed Orthodontics on Patients with Periodontal Disease Accompanied by Pathological Displacement of Anterior Teeth as Assessed by Inflammatory Factors in Gingival Crevicular Fluid
Cao Yangnan, Huang Wenbo
Department of Stomatology,Nanyang Central Hospital,Nanyang 473000,China
Abstract：Objective To analyze the application value of guided tissue regeneration(GTR) combined with fixed orthodontics in the treatment of periodontal disease accompanied by pathological displacement of the anterior teeth. Methods This study collected data from 80 patients with periodontal disease and pathological displacement of anterior teeth who were admitted and diagnosed for retrospective research.According to the treatment plan,41 patients who underwent GTR were grouped as the control group,and 39 patients who underwent GTR combined with fixed orthodontics were grouped as the study group.The periodontal status,anterior tooth displacement angle,depth of alveolar bone defect,quality of life and inflammatory factors in gingival crevicular fluid were compared between the two groups before and after 6 months of treatment. Results After 6 months of treatment,the study group had lower scores in periodontal pocket depth(PD),SNA angle,bleeding index(SBI),vertical bone absorption depth,gingival crevicular fluid interleukin-6(IL-6),ANB angle,tumor necrosis factor-α(TNF-α),UI-SN angle,matrix metalloproteinase-9(MMP-8),and clinical attachment loss(CAL) than the control group,while the upper central incisor convex angle difference and the score of the General Quality of Life Inventory-74(GQOLI-74) were higher than those of the control group(P<0.05). Conclusion GTR combined with fixed orthodontics is used for periodontal disease with pathological displacement of anterior teeth,effectively improving the periodontal condition,vertical bone absorption depth,anterior tooth displacement,expression of inflammatory factors in gingival crevicular fluid,and improving quality of life.
曹洋楠, 黄文博. 从龈沟液炎性因子分析GTR联合固定正畸治疗牙周病伴前牙病理性移位患者的效果[J]. 哈尔滨医药, 2025, 45(5): 47-50.
Cao Yangnan, Huang Wenbo. Analysis of the Effect of GTR Combined with Fixed Orthodontics on Patients with Periodontal Disease Accompanied by Pathological Displacement of Anterior Teeth as Assessed by Inflammatory Factors in Gingival Crevicular Fluid. journal1, 2025, 45(5): 47-50.
2025, Vol. 45 
