Abstract：Objective To study the influence of diazepam combined with phenobarbital treatmenton the symptom control duration of febrile convulsion in children. Methods 104 cases of febrile convulsion in children were selected and randomly divided into a combined drug group（n=52）and a single drug group（n=52）.The single drug group used diazepam,and the combined drug group added phenobarbital on this basis.The therapeutic effect,drug onset time,convulsion improvement time,body temperature recovery time,hospitalization time,myocardial enzyme levels [creatinephosphate kinase（CK）,lactate dehydrogenase（LDH）,creatine kinase isoenzyme（CKI）],brain nerve related factors [neuropeptide Y（NPY）,neurotrophic factor（BDNF）] andchanges of adverse reactions occurrence rate of the two groups were compared. Results The total effective rate of the combined drug group 94.23%（49/52）washigher than that of the single drug group 73.08%（38/52）,with a statistical difference（P<0.05）;Compared with the single drug group,the drug onset time,convulsion improvement time,body temperature recovery time and hospitalization time of the combined drug group were shorter（P<0.05）;Compared with the single drug group,the levels of CK,CKI and LDH in the combined drug groupafter treatment were lower,with statistical differences（P<0.05）;Compared with the single drug group,the levels of NPY and BDNF in the combined drug groupafter treatment were lower,with statistical differences（P<0.05）;There was no significant difference in the incidence of adverse reactions between the combination group 3.85%（2/52）and the single drug group 11.54%（6/52）（P>0.05）. Conclusion Diazepam combined with phenobarbital in treating febrile convulsions in childrenhas obvious curative effect.It can improve clinical symptoms,regulate the level of myocardial enzymes and the expression of brain nerve factors,and is safe to use,which can be further promoted and applied in clinical practice.
金丹, 陈启胜. 地西泮联合苯巴比妥治疗小儿发热性惊厥症状控制时长的影响[J]. 哈尔滨医药, 2023, 43(4): 35-37.
Jin Dan, Chen Qisheng. Influenceof Diazepam Combined with Phenobarbital Treatmenton Symptom Control Duration of Febrile Convulsion in Children. journal1, 2023, 43(4): 35-37.
[1] 沙文光. 苯巴比妥联合地西泮治疗小儿热性惊厥的疗效分析[J].数理医药学杂志,2020,33(4):596-597. [2] Emilia Gvozdenovic,Volker Vetter,Corinne Willame,et al.Impact of history of febrile convulsions on the risk difference of febrile convulsions with the tetravalent measles-mumps-rubella-varicella vaccine:Post-hoc exploratory analysis of results from a matched-cohort study[J].Vaccine,2018,36(39):5803-5806. [3] 张润春,王玉珍,张静.左乙拉西坦联合地西泮对热性惊厥反复发作儿童损伤因子、炎性因子和免疫因子的影响[J].药物评价研究,2020,43(10):2026-2030. [4] 戴上康,吴元芳,余洽超,等.地西泮联合苯巴比妥治疗小儿热性惊厥的临床疗效及患儿血清学改变[J].中国医药科学,2018,8(10):16-19. [5] 谢云龙,黄伟方,陈丹丹,等.地西泮联合苯巴比妥治疗小儿热性惊厥的疗效及其对平均起效时长的影响[J].临床合理用药杂志,2022,15(9):23-26. [6] 卞晓琴. 地西泮联合苯巴比妥治疗小儿发热性惊厥的效果及对患者心肌细胞的影响[J].医学信息,2021,34(21):115-117. [7] 李永召. 苯巴比妥联合地西泮对急诊惊厥患儿症状改善及预后复发率的影响[J].数理医药学杂志,2018,31(11):1672-1674. [8] 张登科. 地西泮联合苯巴比妥对热性惊厥患儿血清NSE、S-100β、BNDF水平的影响[J].系统医学,2019,4(3):93-95. [9] 龙洁. 咪达唑仑联合苯巴比妥对热性惊厥患儿NSE、S-100β蛋白、BDNF及脑功能预后的影响[J].大医生,2021,6(1):113-115. [10] 李刚,申迎春,张勇.苯巴比妥联合地西泮治疗热性惊厥患儿的临床效果及对血清S-100β与T淋巴细胞亚群的影响[J].解放军医药杂志,2018,30(9):101-104.
2023, Vol. 43 
