The Impact of Non-invasive Ventilator Combined with Antibiotic Step-down Therapy on Respiratory Function in Emergency Severe Pneumonia Patients with Respiratory Failure
Wang Liwei, Song Xiangkui, Wan Zhenzhen
Emergency Comprehensive Ward of Zhengzhou First People's Hospital,Zhengzhou,Henan 450000,China
Abstract：Objective To observe the clinical therapeutic value of using a ventilator combined with antibiotics to lower the ladder in the treatment of emergency severe pneumonia patients with respiratory failure.Method 80 patients diagnosed with emergency severe pneumonia complicated with respiratory failure were selected.The patients were randomLy divided into a control group and a study group,with 40 patients in each group,using a random number table method.The control group was given antibiotics to reduce the risk of respiratory failure,while the study group received non-invasive ventilators on top of the control group.The respiratory function of both groups of patients was analyzed,including dynamic lung compliance（Cdyn）,work of breathing（WOB）,oxygenation index（PaO2/FiO2）,heart rhythm,respiratory rate,and cardiac function,including left ventricular end diastolic diameter（LVEDD）,left ventricular ejection fraction（LVEF）,inflammatory factors such as C-reactive protein（CRP）,tumor necrosis factor（tumor necrosis factor）.Necrosis factor（TNF-α）,total adverse reaction rate,and overall efficacy rate.Result After treatment,Cdyn,WOB,PaO2/FiO2,and LVEF in both groups of patients were higher than before treatment（P<0.05）;Heart rate,respiratory rate,LVEDD,CRP,and TNF -αwere lower than before treatment（P<0.05）;The total adverse reaction rate of the research group was relatively low,and the total effective rate was relatively high（P<0.05）.Conclusion The combination of non-invasive ventilator and antibiotic ladder descent can effectively improve the respiratory function of emergency severe pneumonia patients with respiratory failure,and the overall effective rate is high,which is worthy of clinical promotion.
王利伟, 宋向奎, 万真真. 无创呼吸机联合抗生素降阶梯治疗急诊重症肺炎合并呼吸衰竭患者对呼吸功能的影响[J]. 哈尔滨医药, 2025, 45(2): 1-3.
Wang Liwei, Song Xiangkui, Wan Zhenzhen. The Impact of Non-invasive Ventilator Combined with Antibiotic Step-down Therapy on Respiratory Function in Emergency Severe Pneumonia Patients with Respiratory Failure. journal1, 2025, 45(2): 1-3.
2025, Vol. 45 
