Comparative Observation of the Clinical Efficacy of the Same Scheme in the Treatment of Simple Pulmonary Tuberculosis and Pulmonary Tuberculosis with Diabetes
Zhong Bing1, Jiao Jie2, Li Fangfei1, Lin Biding1,*
1. Department of infectious diseases,Fuding City Hospital,Fujian 355200; 2. Respiratory Department of Fuding Hospital,Fuding 355200,Fujian
Abstract：Objective To compare the therapeutic effects of the same antituberculosis methods on simple pulmonary tuberculosis and pulmonary tuberculosis with diabetes,so as to provide corresponding reference for clinical treatment scheme selection. Methods 120 patients with pulmonary tuberculosis were selected and divided into group A(75 cases) with simple pulmonary tuberculosis according to whether they have diabetes or not;45 patients in group B with pulmonary tuberculosis and diabetes.In terms of treatment method selection,both groups of patients were intervened with the 2RHZE/4HR anti tuberculosis treatment regimen,which lasted for 6 months.Compare the efficacy,sputum conversion,immune function,and adverse reaction indicators of two groups of research subjects. Results After 6 months of intervention,there was no significant difference in the total effective rate of treatment between the observation group and the control group (89.33% vs 91.11%,P>0.05).The sputum conversion rates after 1 month,3 months,and 6 months of treatment were 72.00%,85.33%,and 94.67% in the observation group,and 40.00%,48.89%,and 66.67% in the control group,respectively.The sputum conversion rates in the observation group were higher than those in the control group at different stages after treatment(P<0.05).After 6 months of treatment,the peripheral blood T lymphocyte subsets CD3+,CD4+,CD4+/CD8+in both groups of patients increased,while CD8+decreased.The changes in these indicators were more significant in the observation group compared to the control group(P<0.05).There was no significant difference in adverse reactions between the comparison groups(P>0.05). Conclusion The same antituberculosis program intervenes in pulmonary tuberculosis with simple or combined diabetes,and the treatment effect is different.In diabetes,the antituberculosis drug intervention has poor effect on sputum bacteria negative,and at the same time,the improvement of immune function is poor.Therefore,in practice,it is necessary to cooperate with certain blood glucose control when treating pulmonary tuberculosis with diabetes,and then combine the antituberculosis program intervention to achieve good treatment effect.
钟兵, 矫捷, 李芳斐, 林必定. 相同方案治疗单纯性肺结核与肺结核合并糖尿病的临床疗效对照观察[J]. 哈尔滨医药, 2025, 45(5): 9-11.
Zhong Bing, Jiao Jie, Li Fangfei, Lin Biding. Comparative Observation of the Clinical Efficacy of the Same Scheme in the Treatment of Simple Pulmonary Tuberculosis and Pulmonary Tuberculosis with Diabetes. journal1, 2025, 45(5): 9-11.
2025, Vol. 45 
