The Effect of Stepped Decompression Treatment on the State of Consciousness and Serum miR-34a and miR-16 in Brain Injured Patients with Ventricular Intracranial Pressure Monitoring
Li Hao, Zhang Hailong
Department of Neurosurgery,Xinyang Central Hospital,Xinyang 464099,Henan,China
Abstract：Objective To explore the influence of stepped decompression under ventricular intracranial pressure monitoring on status of consciousness and serum miR-34a and miR-16 in brain injury patients. Methods The 120 patients with craniocerebral trauma were divided into the observation group(n=63) and the control group(n=57).The control group underwent traditional decompression,and the observation group received ventricular intracranial pressure monitoring on the basis of the control group.The two groups were compared in terms of clinical efficacy,intracranial pressure level,neurological function and occurrence of complications. Results Compared with control group,the clinical efficacy in observation group was better(P<0.05).At 1 d,3 d and 1 w after surgery,both groups showed a stepwise decrease in intracranial pressure,and the observation group had lower intracranial pressure compared to control group(P<0.05).The score of Coma Recovery Scale-Revised(CRS-R) after treatment was increased in both groups,and the CRS-R scale score was higher in observation group(P<0.05).The levels of miR-34a and miR-16 in both groups were decreased after treatment,and the levels in observation group were lower(P<0.05).The incidence rates of intracranial infection,delayed hematoma,gastrointestinal bleeding,and renal insufficiency were similar between the two groups(P>0.05),but compared with control group,the incidence rate of acute encephalocele was lower in observation group(P<0.05). Conclusion The ventricular intracranial pressure monitoring combined with stepped decompression can effectively treat patients with craniocerebral injury,improve their nerve function,and reduce the risk of intraoperative acute encephalocele.
李浩, 张海龙. 脑室型颅内压监测下阶梯性减压治疗对颅脑损伤患者意识状态及血清miR-34a、miR-16的影响[J]. 哈尔滨医药, 2025, 45(5): 18-21.
Li Hao, Zhang Hailong. The Effect of Stepped Decompression Treatment on the State of Consciousness and Serum miR-34a and miR-16 in Brain Injured Patients with Ventricular Intracranial Pressure Monitoring. journal1, 2025, 45(5): 18-21.
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2025, Vol. 45 
