Abstract：Objective Exploring the relationship between serum FGF-23 levels and the progression of end-stage renal disease in patients with chronic kidney disease. Methods Select 97 end-stage renal disease(ESRD)patients undergoing hemodialysis at the Seventh Affiliated Hospital of Xinjiang Medical University between July,along with 30 healthy individuals receiving routine health examinations during the same period as the control group.Compare baseline characteristics,blood biochemical markers,and renal function parameters between the two groups.Evaluate clinical indicators and cardiorenal parameters across different CKD stages,and analyze the correlation between FGF-23 and renal function. Results The observation group exhibited significantly higher systolic blood pressure,diastolic blood pressure,mean arterial pressure,serum uric acid,and FGF-23 levels compared to the control group,while estimated glomerular filtration rate was lower(P<0.05).After treatment,the observation group showed significant reductions in BUN,SCr,FGF-2,FGF-23,Cyc-C,eGFR,left ventricular mass index,and ejection fractioncompared to pretreatment levels,whereas creatinine clearance rateincreased(P<0.05).Across the five CKD stages,eGFR progressively declined with disease progression,while parathyroid hormone(PTH)levels gradually increased.Significant intergroup differences were observed in uric acid,FGF-23,BUN,SCr,Ccr,FGF-2,Cyc-C,eGFR,PTH,LVMI,and LVEF(P<0.05).FGF-23 correlated negatively with BUN,SCr,Cyc-C,PTH,LVMI,and LVEF.BUN and SCr showed significant negative correlations with LVMI,LVEF,and eGFR but positive correlations with Cyc-C,FGF-2,and PTH.eGFR positively correlated with LVMI and LVEF but negatively with PTH.Cyc-C demonstrated a strong negative correlation with LVEF,while LVMI and LVEF were inversely related(all P<0.05). Conclusion FGF-23 can serve as an early and sensitive biomarker for the progression of chronic kidney disease to CKD,helping to identify high-risk patients at risk of early or rapid disease progression.High levels of FGF-23 are important factors in predicting the progression of end-stage renal disease(ESRD)in CKD patients.In the future,treatment strategies targeting FGF-23 can be developed and standardized testing can be promoted to break the vicious cycle of promoting CKD progression and cardiovascular damage.
王永磊, 樊佳佳, 何岩岩. 血清FGF-23水平与慢性肾病患者进展为终末期肾病的关系[J]. 哈尔滨医药, 2026, 46(1): 15-19.
Wang Yonglei, Fan Jiajia, He Yanyan. The Relationship between Serum FGF-23Levels, the Progression of Chronic Kidney Disease to End-stage Renal Disease in Patients. journal1, 2026, 46(1): 15-19.
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2026, Vol. 46 
