Abstract：Objective To study the combined diagnostic value of N-terminal pro-C-type natriuretic peptide（NT-proCNP）,interleukin-8（IL-8）and tumor necrosis factor-α（TNF-α）in sepsis-associated encephalopathy（SAE）. Methods A total of 80 patients with sepsis and septic shock were prospectively selected as the research objects.Taking the results of imaging-assisted examinations such as MRI and EEG as the clinical results of whether the patients had SAE,the patients were divided into the SAE group and the non-SAE group.The levels of NT-proCNP,IL-8 and TNF-α in the patients were detected,and the values of individual diagnosis and combined diagnosis were analyzed. Results The area under the curve（AUC）of NT-proCNP in diagnosing SAE was 0.844,the specificity was 0.846,and the sensitivity was 0.722;the AUC of IL-8 in diagnosing SAE was 0.869,the specificity was 0.962,and the sensitivity was 0.685;the AUC of TNF-α in diagnosing SAE was 0.886,the specificity was 0.885,and the sensitivity was 0.796;the AUC of the three combined in diagnosing SAE was 0.991,the specificity was 0.962,and the sensitivity was 0.981;the Delong test results showed that the efficiency of combined diagnosis of SAE was higher than that of individual diagnosis of SAE by NT-proCNP,IL-8 and TNF-α levels（Z=3.221,3.241,3.144,all P<0.05）. Conclusion The levels of NT-proCNP,IL-8 and TNF-α can be used as potential biological indicators for diagnosing SAE.The combined diagnosis of the three has excellent diagnostic efficiency,can help clinically and accurately diagnose whether patients have SAE,provide help for clinical treatment decisions,and can be popularized in clinical practice.
郭树平, 廖春燕, 刘清红, 黄庆飞. 联合血清标志物NT-proCNP、白细胞介素-8及肿瘤坏死因子-α对脓毒症相关性脑病诊断价值的相关研究[J]. 哈尔滨医药, 2025, 45(3): 34-36.
Guo Shuping, Liao Chunyan, Liu Qinghong, Huang Qingfei. Research on the Diagnostic Value of Combined Serum Markers NT-proCNP,Interleukin-8 and Tumor Necrosis Factor-α in Sepsis-Associated Encephalopathy. journal1, 2025, 45(3): 34-36.
2025, Vol. 45 
