Research Progress in the Diagnosis and Treatment of Chronic Endometritis
Wang Kexin1, Jiao Yonghui2, *
1. Graduate School of Xinjiang Medical University,Urumqi,Xinjiang 830054,China; 2. Department of Reproductive Medicine, People's Hospital of xinjiang uygur Autonomous Region,,Urumqi,Xinjiang 830001,China
Abstract:Chronic endometritis(CE)is a chronic inflammatory condition of the endometrium that may alter both its structure and physiological function,thereby affecting embryo implantation and the maintenance of pregnancy.Due to its frequent lack of specific clinical manifestations,CE is often underdiagnosed.Recent studies have shown a gradual increase in its prevalence,with its adverse impact on reproductive outcomes becoming increasingly significant.This review aims to summarize recent innovations in the diagnosis and treatment of CE through a comprehensive analysis of relevant literature,with the goal of providing a reference for standardized clinical management and future research directions.
王可欣, 焦永慧. 慢性子宫内膜炎诊断与治疗的研究进展[J]. 哈尔滨医药, 2026, 46(1): 135-138.
Wang Kexin, Jiao Yonghui. Research Progress in the Diagnosis and Treatment of Chronic Endometritis. journal1, 2026, 46(1): 135-138.
[1] KITAYA K,TAKEUCHI T,MIZUTA S,et al.Endometritis:new time,newconcepts[J].Fertil Steril,2018,110(3):344-350. [2] KITAYA K.Prevalence of chronic endometritis in recurrent miscarriages[J].Fertil Steril,2011,95(3):1156-1158. [3] 严罗镓,金碧辉,舒静.慢性子宫内膜炎与女性生殖功能的关系研究进展[J].浙江医学,2022,44(07):771-776. [4] 王梦婷. 慢性子宫内膜炎的诊治对反复着床失败患者妊娠结局的影响及机制研究[D].华中科技大学,2023. [5] MCQUEEN D B,PERFETTO C O,HAZARD F K,et al.Pregnancy outcomes in women with chronic endometritis and recurrent pregnancy loss[J].Fertil Steril,2015,104(4):927-931. [6] KITAYA K,MATSUBAYASHI H,TAKAYA Y,et al.Live birth rate following oral antibiotic treatment for chronic endometritis in infertile women with repeated implantation failure[J].American Journal of Reproductive Immunology,2017,78(5). [7] SANTORO A,TRAVAGLINO A,INZANI F,et al.The role of plasma cells as a marker of chronic endometritis:a systematic review and meta-analysis[J].Biomedicines,2023,11(6):1714. [8] CICINELLI E,RESTA L,NICOLETTI R,et al.Detection of chronic endometritis at fluid hysteroscopy[J].Journal of Minimally Invasive Gynecology,2005,12(6):514-518. [9] MORENO I,CICINELLI E,GARCIA-GRAU I,et al.The diagnosis of chronic endometritis in infertile asymptomatic women:a comparative study of histology,microbial cultures,hysteroscopy,and molecular microbiology[J].Am J Obstet Gynecol,2018,218(6):602 e601-602 e616. [10] Mcqueen DB,Bernardi LA,Stephenson MD.Chronic en-dometritis in womenwith recurrent early pregnancy loss and /or fetal demise[J].Fertility and Sterility,2014,101(4):1026-1030. [11] Kitaya K,Matsubayashi H,Takaya Y,et al.Live birth rate following oralantibiotic treatment for chronic endometritis in infertile women with repeated implantation failure[J].Am J Reprod Immunol,2017,78(5). [12] 林明媚,李蓉.慢性子宫内膜炎对女性生育结局影响的研究进展[J].中华医学杂志,2024,104(20):1893-1897. [13] Qu D,Yang M,Tong L,et al.Combination of dydrogesterone and antibiotic versus antibiotic alone for chronic endo-metritis:a randomized controlled trial study[J].Reprod Sci,2021,28(11):3073-3080. [14] Workowski KA,Bachmann LH,Chan PA,et al.Sexually Transmitted Infections Treatment Guidelines,2021[J].MMWR Recomm Rep,2021,70(4):1-187. [15] 赵静,黄国宁,孙海翔,等.辅助生殖技术中异常子宫内膜诊疗的中国专家共识[J].生殖医学杂志,2018,27(11):1057-1064. [16] 王修竹,陈学梅,刘雪梅.慢性子宫内膜炎发病机制及诊疗进展[J].国际妇产科学杂志,2023,50(1):102-108. [17] Hadrian P,Dorothea KK,Solving D,et al.Platelet-rich plas-ma(PRP):compositionzl analysis with different dietary habits and timing of biood sampling.[J].Ort hopadie(Hei-delberg,Germany),2023,52(11):907-915. [18] KARADBHAJNE P,DZOAGBE H Y,MORE A.Plateletrich plasma(PRP)for endometrial treatment efficacy and safety in assisted reproductive technology:a comprehensive review[J].Cureus,2024,16(5):59728. [19] 杨莉,杨晓棠,王丽霞,等.自体富血小板血浆治疗复发性流产的临床研究[J].现代妇产科进展,2024,33(10):767-770. [20] 王文婷,王晓清,李颖,等.自体富血小板血浆在慢性子宫内膜炎临床治疗中的效果分析[J].中国输血杂志,2025,38(4):546-550. [21] Moreno I,Garcia-GrauI,BauD,et al.The first glimpse of the endometrial microbiota in early pregnancy[J].Am J ObstetGynecol,2020,222:296-305. [22] Chen W,Wei K,He X,et al.Identification of uterine microbiotain infertile women receiving in vitro fertilization with and without chronic endometritis[J].FrontCellDev Biol,2021,9:693267. [23] 王静怡,袁莹,邹志玲,等.微生物感染在慢性子宫内膜炎致生殖障碍中的机制进展[J].生殖医学杂志,2024,33(01):122-128. [24] CICINELLI E,MATTEO M,TINELLI R,et al.Prevalence of chronic endometritis in repeated unexplained implantation failure and the IVF successrate after antibiotic therapy[J].Hum Reprod,2015,30(2):323-330. [25] Wang J,Li Z,Ma X,et al.Translocation of vaginal microbiota is involved in impairment and protection of uterine health[J].Nat Commun,2021,12(1):4191. [26] 鄢晨菲,朱亚男,兰艳丽,等.慢性子宫内膜炎的诊断和治疗研究进展[J].中国现代医学杂志,2025,35(18):48-53. [27] 李冬兰,徐燕文,杨丽娟.慢性子宫内膜炎的中西医诊疗进展[J].中国妇幼保健,2025,40(22):4260-4263. [28] 关心怡,赵春梅,鲁敏,等.中药灌肠联合多西环素?甲硝唑治疗合并慢性子宫内膜炎的不孕患者的临床研究[J].中国当代医药,2024,31(10):84-87. [29] 鲁改娟,王文娟,常瑛瑛,等.中西医结合治疗慢性子宫内膜炎性不孕临床观察[J].光明中医,2024,39(16):3301-3304. [30] 胡亦然,蔡平平.中西医结合治疗慢性子宫内膜炎疗效的Meta分析[J].湖南中医杂志,2021,37(09):145-151.