Abstract：Objective To compare the effects of irbesartan and benazepril on coronary artery disease（CHD） with hypertension（EH） on vascular endothelial function parameters.Methods A total of 120 patients with CHD and EH were selected as test subjects and randomly divided into a study group and a control group of 60 cases each.The control group was treated with benazepril and the study group was treated with irbesartan.The changes of vascular endothelial function indexes（NO,ET-1） and morning blood pressure（DBP,SBP） of the two groups of patients were compared before and after 1 month of treatment,and the differences in adverse drug reactions within 1 month of treatment were analyzed.Results After 1 month of treatment,the levels of NO in the two groups were significantly higher than before treatment,and the study group was significantly higher than the control group in the same period（P<0.05）.The levels of ET-1 in the two groups were significantly lower than before treatment,and the study group was significantly lower than the control group at the same time（P<0.05）.In the morning,the levels of DBP and SBP in the two groups were significantly lower than before treatment（P<0.05）,and the levels of DBP and SBP between the two groups were not statistically significant（P>0.05）.Within 1 month of treatment,the incidence of dry cough in the study group was significantly lower than that in the control group（P<0.05）.There were no significant differences in other adverse drug reactions（P>0.05）.Conclusion Irbesartan is effective in treating CHD with EH,which is equivalent to benazepril,but irbesartan can significantly improve the level of vascular endothelial function in patients with CHD and EH,and the safety is better than benazepril,which is beneficial to the recovery of patients' prognosis.
2021, Vol. 41 
