Study on Clinical Effect and Mechanism of Ganmaiqixian Magnetic Stone Decoction Combined with Conventional Sleeping Medicine on Elderly Patients with Chronic Insomnia
Xian Zhiqiang, Zhuang Kun, Wen Nannan
Department of Rehabilitation Medicine,Dancheng People's Hospital,Zhoukou 477150,China
Abstract：Objective To explore the clinical efficacy and mechanism of Ganmai Qixian Magnetic Stone Decoction combined with conventional sleeping drugs in elderly patients with chronic insomnia due to heart and spleen deficiency.Methods From September 2018 to December 2019,64 elderly patients with senile insomnia who were dialectic of TCM and Spleen Deficiency were selected as the research subjects,and were divided into observation group and control group according to the random number table method.(32 cases each).The control group was given conventional sleeping medication,and the observation group was given Ganmai Qixian Magnet Decoction on the basis of the control group.The clinical efficacy and TCM symptom scores,norepinephrine(NE)and 5- Serotonin(5-HT)levels,sleep quality.Results The total effective rate of clinical efficacy in the observation group was higher than that in the control group(93.75% vs 75.00%,P<0.05),and the total effective rate of TCM symptoms was higher than the control group(93.75% vs 71.88%,P<0.05);after treatment The NE level decreased and 5-HT level increased in both groups(P<0.05).The sleep quality in both groups was improved(P<0.05),and the improvement in the observation group was better than that in the control group(P<0.05).Conclusion Ganmaiqixian Magnetic Stone Decoction combined with conventional sleep medicine can effectively improve the clinical symptoms of elderly patients with chronic insomnia with heart and spleen deficiency.The effect is more obvious than that of conventional sleep medicine alone,and its mechanism may be through affecting the brain 5- The contents of HT and NE act on the sleep-wake cycle.
咸志强, 庄坤, 温楠楠. 甘麦芪仙磁石汤结合常规安眠药物对老年心脾两虚型慢性失眠患者的临床疗效以及作用机制研究[J]. 哈尔滨医药, 2021, 41(3): 123-125.
Xian Zhiqiang, Zhuang Kun, Wen Nannan. Study on Clinical Effect and Mechanism of Ganmaiqixian Magnetic Stone Decoction Combined with Conventional Sleeping Medicine on Elderly Patients with Chronic Insomnia. journal1, 2021, 41(3): 123-125.
2021, Vol. 41 
