Clinical Effect of Invasive-Noninvasive Sequential Mechanical Ventilation on Patients With Severe Chronic Obstructive Pulmonary Disease and Respiratory Failure
Zhao Shuai
Emergency Department,Kaifeng Hospital of traditional Chinese Medicine,Kaifeng 475000,China
Abstract：Objective To investigate the clinical effect of invasive-noninvasive sequential mechanical ventilation in the treatment of severe chronic obstructive pulmonary disease patients with respiratory failure. Methods A total of 86 patients with severe chronic obstructive pulmonary disease and respiratory failure were selected and divided into experimental group（n=43）and control group（n=43）according to the random number table.The control group received continuous invasive mechanical ventilation,and the experimental group received invasive-noninvasive sequential mechanical ventilation.The mechanical ventilation time,hospitalization time,blood gas indexes（PaO2,PaCO2）,lung function（PEF,FEV1）and the incidence of ventilator-associated pneumonia（VAP）before and after treatment were compared between the two groups. Results The invasive mechanical ventilation time,total mechanical ventilation time,and hospital stay in the experimental group were shorter than those of the control group（P<0.05）,after treatment,the experimental group had higher PaO2 and lower PaCO2 than the control group（P<0.05）.After treatment,PEF and FEV1 in the experimental group were higher than those in the control group（P<0.05）.The incidence of VAP of the experimental group and the control group were 2.33%（1/43）and 11.63%（5/43）,there was no significant difference in comparison（P>0.05）. Conclusion Invasive-noninvasive sequential mechanical ventilation for severe chronic obstructive pulmonary disease patients with respiratory failure can improve blood gas indicators,improve patients’ pulmonary function,shorten the time of mechanical ventilation,prevent VAP,speed up the patient’s recovery process,and shorten the hospital stay.
2021, Vol. 41 
