卡左双多巴控释片联合多巴丝肼片对帕金森病患者血浆Hcy、叶酸水平的影响

doi:10.3969/j.issn.1001-8131.2022.01.005

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摘要目的研究卡左双多巴控释片联合多巴丝肼片对帕金森病（Parkinson's disease,PD）患者血浆同型半胱氨酸（Homocysteine,Hcy）、叶酸水平的影响。方法将86例PD患者按照信封法随机分为联用组与对照组,各43例,对照组接受口服多巴丝肼片,联用组治疗方法是卡左双多巴控释片+多巴丝肼片。观察两组患者的总有效率及不良反应,同时将两组患者认知功能（MMSE、MoCA评分）及血浆叶酸、Hcy含量进行治疗前后对比。结果联用组治疗总有效率为88.37%,较对照组的69.77%显著高（P<0.05）;两组治疗后叶酸较治疗前明显升高,Hcy较治疗前明显下降,且联用组治疗后叶酸明显高于对照组,Hcy明显低于对照组（P<0.05）;两组治疗后MMSE、MoCA评分较治疗前均明显上升,且联用组治疗后各评分均比对照组明显高（P<0.05）;联用组不良反应总发生率为13.95%,较对照组的16.28%差异无统计学意义（P>0.05）。结论对PD患者采用联合多巴丝肼片、卡左双多巴控释片治疗的疗效较好,能显著改善患者认知功能及血浆Hcy、叶酸水平。

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关键词 ：卡左双多巴控释片, 叶酸, 帕金森, 同型半胱氨酸, 多巴丝肼片

Abstract：Objective To study the effects of Carbidopa and Levodopa Controlled Release Tablets combined with Levodopa and Benserazide Hydrochloride Tablets on plasma homocysteine（Hcy）and folic acid levels in patients with Parkinson's disease（PD）. Methods 86 patients with PD who were diagnosed and treated in the hospital were randomized into combined group and control group,43 cases in each group.The control group was treated with oral Levodopa and Benserazide Hydrochloride Tablets,and the combined group was treated with Carbidopa and Levodopa Controlled Release Tablets combined with Levodopa and Benserazide Hydrochloride Tablets.The total response rates and adverse reactions of the two groups were observed.Meanwhile,cognitive function（MMSE and MoCA scores）and plasma folic acid and Hcy levels of the two groups were compared before and after treatment. Results The total response rate of combined group（88.37%）was significantly higher than that of the control group（69.77%）（P<0.05）.After treatment,folic acid levels of both groups were significantly increased,and Hcy levels were significantly reduced.Besides,the folic acid level of combined group was significantly higher than that of the control group,and Hcy level was significantly lower than the control group（P<0.05）.After treatment,MMSE and MoCA scores of both groups were significantly increased.Besides,the scores of combined group were significantly higher than those of the control group（P<0.05）.There was no significant difference in the total incidence of adverse reactions between the 2 groups（13.95% vs.16.28%）（P>0.05）. Conclusion Carbidopa and Levodopa Controlled Release Tablets combined with Levodopa and Benserazide Hydrochloride Tablets are effective in treatment of PD,which can significantly improve cognitive function and plasma Hcy,folic acid levels.

Key words： Carbidopa and levodopa controlled release tablets Folic acid Parkinson Homocysteine Levodopa and benserazide hydrochloride tablets

收稿日期: 2020-12-08

PACS:

R742.5

引用本文:

牛晓波. 卡左双多巴控释片联合多巴丝肼片对帕金森病患者血浆Hcy、叶酸水平的影响[J]. 哈尔滨医药, 2022, 42(1): 11-13.
Niu Xiaobo. Effects of Carbidopa and Levodopa Controlled Release Tablets Combined With Levodopa and Benserazide Hydrochloride Tablets on Plasma Hcy and Folic Acid Levels in Patients With Parkinson's Disease. journal1, 2022, 42(1): 11-13.

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http://www.hrbyybjb.org.cn/CN/10.3969/j.issn.1001-8131.2022.01.005 或 http://www.hrbyybjb.org.cn/CN/Y2022/V42/I1/11

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