Abstract：Objective To investigate the therapeutic effect and influencing factors of immunotherapy for aplastic anemia（AA）. Methods 70 AA patients treated were selected.All patients were treated with immunotherapy（cyclosporine + antithymocyte globulin）for 6 months.The treatment effect was evaluated and recorded according to relevant standards,and divided into effective group and ineffective group;Design a general data questionnaire,ask and record the general data and laboratory related indicators of patients,and analyze the influencing factors of immunotherapy in AA patients. Results After 6 months of immunotherapy in 70 AA patients,45 cases were evaluated as effective,and the effective rate was 64.29%（45 / 70）;25 cases were evaluated as ineffective,and the ineffective rate was 35.71%（25 / 70）;Before treatment,the absolute value of neutrophils（ANC）and reticulocyte count（RET）in the ineffective group were lower than those in the effective group,and the hematopoietic area of bone marrow was smaller than that in the ineffective group（P<0.05）;Logistic regression analysis showed that high levels of RET and ANC and large hematopoietic area of bone marrow were the protective factors for the ineffective treatment of AA immunotherapy（or<1,P<0.05）. Conclusion High levels of ANC and RET and large hematopoietic area of bone marrow are the protective factors for the therapeutic effect of AA immunotherapy.
2022, Vol. 42 
