Abstract：Objective To analyze the differentially expressed miRNAs associated with preeclampsia,select miR-152 predicted target genes and perform bioinformatics analysis to explore the molecular mechanisms involved in the pathogenesis of preeclampsia. Methods The most significantly upregulated miR-152 in the dataset GSE103542 was selected as the study target,and its target genes were predicted and taken for intersection.GO functional annotation and KEGG pathway enrichment analysis of the intersecting target genes were performed using the DAVID network online enrichment tool,and the STRING website was used to analyze their protein interactions. Results The 418 intersecting target genes obtained are mainly involved in biological processes such as bioadhesion,cell adhesion and cell developmental regulation;in cell composition,they are mainly involved in plasma membrane components,lattice protein vesicles;in molecular functions,they are mainly involved in calcium binding,ion binding.KEGG signaling pathway enrichment analysis showed that it was mainly involved in signaling pathways regulating stem cell pluripotency and TGF signaling pathway.Protein interaction analysis showed that IGF1R,SMAD3,RPS6KB1 and PPP2CA were the key nodes of the protein interaction network. Conclusion miR-152 may affect trophoblast proliferation,invasion and apoptosis through the TGF signaling pathway in multiple ways in the development of pre-eclampsia.
杨倩文, 陶峰, 陈红波. 基于生物信息学分析miR-152在子痫前期发病机制中的作用[J]. 哈尔滨医药, 2023, 43(2): 1-4.
Yang Qianwen, Tao Feng, Chen Hongbo. Bioinformatics-based Analysis of The Role of miR-152 in The Pathogenesis of Pre-eclampsia. journal1, 2023, 43(2): 1-4.
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2023, Vol. 43 
