Abstract：Objective To investigate the correlation between serum levels of heparin-binding epidermal growth factor（HB-EGF）and growth differentiation factor 15（GDF15）and the prognosis of patients with ovarian cancer undergoing surgical treatment.Methods A prospective randomized trial method was used to select 90 patients with ovarian cancer who received surgical treatment as the research objects.All the selected patients received serum HB-EGF and GDF15 levels before surgery,followed up for 3 years,observed the prognosis of patients,and analyzed the correlation between serum HB-EGF and GDF15 levels and the prognosis of patients with ovarian cancer surgically treated.Results Among the 90 ovarian cancer patients,14 had poor prognosis,accounting for 15.56%;76 had good prognosis,accounting for 84.44%;the serum HB-EGF and GDF15 levels in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant（P<0.05）.general bivariate Pearson correlation analysis found that serum HB-EGF and GDF15 levels were positively correlated with the occurrence of poor prognosis（r>0,P<0.05）;ROC curve was drawn,the results showed that serum HB-EGF and GDF15 levels predicted The AUCs of poor prognosis were all>0.8,which had a certain predictive value.Conclusion The levels of serum HB-EGF and GDF15 in patients with ovarian cancer are closely related to the prognosis after surgical treatment.In the future,the detection of serum HB-EGF and GDF15 levels can be used to evaluate the prognosis of patients with ovarian cancer and provide a reference for early prevention and treatment.
2023, Vol. 43 
