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| Toxicity Assessment and Safety Experimental Study of the Drug Bevacizumab |
| Lou Renjie |
| University of California,Davis Shields Ave Davis,CA 95616 United States |
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Abstract The article discusses the importance of drug toxicity assessment and how to reduce drug toxicity through modifications of chemical structures.It details an experiment on the toxicity assessment of an anticancer drug（Bevacizumab）.The experiment used both animal models and cell culture methods to comprehensively evaluate the safety of Bevacizumab.The results showed that Bevacizumab exhibited certain toxicity to rats and human liver cell culture systems at high doses or concentrations.It is recommended that further drug development should involve optimization of chemical structures to reduce potential toxicity risks.This research not only provides important safety data for further drug development but also offers a comprehensive experimental model for drug toxicity assessment.
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Received: 11 March 2024
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[1] 聂嘉璇,钱文秀,王曼姝,等.中药毒性相关数据库的研究现状及对比研究[J].中草药,2023,54(22):7588-7596.
[2] 李明奇. 度洛西汀的动物急性毒性试验[J].哈尔滨医药,2008,(05):13.
[3] 孙虹,方俭生.氨基糖甙类抗生素的耳毒性作用机理[J].哈尔滨医药,1993,(01):64-68.
[4] B.Gutyj,et al.Research on acute and chronic toxicity of the experimental drug Amprolinsyl.Publication Date:2017.
[5] Yun Li Zhao,et al.Acute and Sub-chronic Toxicity of Indole Alkaloids Extract from Leaves of Alstonia scholaris(L.)R.Br.in Beagle Dogs.Publication Date:2020.
[6] 张志丽. 利多卡因严重毒性反应1例[J].哈尔滨医药,2003,(02):64. |
| [1] |
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| [2] |
. [J]. journal1, 2024, 44(3): 92-95. |
| [3] |
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2024, Vol. 44 
