高脂血症型急性胰腺炎患者CRRT不同介入时机的乳酸清除率与治疗28天生存率的比较研究

doi:10.3969/j.issn.1001-8131.2025.06.003

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Abstract Objective To investigate the impact of different initiation timings of continuous renal replacement therapy(CRRT)on lactate clearance rate and 28-day survival in patients with hyperlipidemic acute pancreatitis. Methods 98 patients with hyperlipidemic acute pancreatitis admitted to our hospital from January were selected retrospectively and included in the case group.According to the intervention opportunity of CRRT,they were divided into early group(53 cases)and late group(45 cases),and the clinical data,lactate clearance rate and serological indexes of the two groups were compared.Kaplan-Meier survival analysis patients' 28-day survival rate. Results There was no significant difference in age,sex and respiratory rate between the early group and the late group(P>0.05).The 24-hour lactate clearance rate and 48-hour lactate clearance rate in early group were significantly higher than those in late group and,respectively(P<0.05).After treatment,the levels of AMY,TNF-αmL,IL-1βand PCT in the early group.Kaplan-Meier survival analysis showed that the overall survival rate of early group was,which was significantly higher than that of late group（P<0.05）. Conclusion Early CRRT intervention significantly enhances lactate clearance,reduces inflammatory markers,and improves 28-day survival rates in hyperlipidemic acute pancreatitis(HLAP)patients,demonstrating its efficacy as a therapeutic strategy for prognosis improvement.

Key words： Hyperlipidemic acute pancreatitis Continuous Renal Replacement Therapy Intervention timing Lactate clearance 28-day survival rate

Received: 22 July 2025

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R657.5+1

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	Articles by authors
	Zheng Zhiheng
	Zhang Leiming
	Zhu Guoqiang
	Xiao Jingjing

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Zheng Zhiheng,Zhang Leiming,Zhu Guoqiang, et al. Comparative Study on Lactate Clearance Rate and 28-day Survival Rate of Patients with Hyperlipidemia Acute Pancreatitis Treated with CRRT at Different Intervention Opportunities[J]. journal1, 2025, 45(6): 10-13.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2025.06.003 OR http://www.hrbyybjb.org.cn/EN/Y2025/V45/I6/10

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