艾司氯胺酮防治椎管内麻醉后寒战的研究进展

doi:10.3969/j.issn.1001-8131.2026.02.039

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Abstract The occurrence of chills after spinal anesthesia is relatively common,mainly related to the inhibition of hypothalamic thermoregulation centers by anesthetic drugs,resulting in abnormal thermogenesis response.Chills not only cause discomfort and anxiety in patients,but can also increase the risk of complications,delay postoperative recovery,prolong hospital stay,and increase healthcare costs.In recent years,esketamine,as a dextrorotator of ketamine,has gained attention in perioperative management due to its unique pharmacological properties.Studies have shown that it may reduce the incidence of chills after neuraxial anesthesia by regulating body temperature regulation points or inhibiting the downward conduction of chills commands,and its psychomotor adverse effects are milder than ketamine.The purpose of this article is to review the current situation of chills after spinal anesthesia,explore the pharmacological properties of esketamine and its application in the prevention and treatment of chills,and evaluate its efficacy and safety,in order to provide reference for clinical practice.

Key words： Esketamine Spinal anesthesia Chill Perioperative

Received: 10 February 2026

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R971+.2

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	Articles by authors
	Wang Yuanyuan
	Zhang Lei

Cite this article:

Wang Yuanyuan,Zhang Lei. Research Progress on Esketamine in the Prevention and Treatment of Chills after Spinal Anesthesia[J]. journal1, 2026, 46(2): 134-136.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2026.02.039 OR http://www.hrbyybjb.org.cn/EN/Y2026/V46/I2/134

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