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| Expression and Correlation of Ki-67 and p53 in High-Grade Intraepithelial Neoplasia and Adenocarcinoma of the Colorectum |
| Qu Chengyuan, Ye Qinglong, Chen Jing |
| Department of Gastroenterology,Guangdong Provincial People's Hospital,Zhuhai Hospital(Jinwan Central Hospital of Zhuhai,Zhuhai 519000,Guangdong,China |
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Abstract Objective To investigate the expression differences and correlations of Ki-67 and p53 in colorectal high-grade intraepithelial neoplasia(HGIN)and adenocarcinoma tissues,thereby providing a reference for clinical risk assessment of malignant transformation. Methods A total of 72 patients with colorectal lesions admitted to our hospital from January 2018 to December 2025 were retrospectively enrolled,including 27 cases of high-grade intraepithelial neoplasia and 45 cases of adenocarcinoma.The protein expressions of Ki-67 and p53 in lesion tissues were detected using the immunohistochemical SP method.Fisher’s exact test was used to correct statistical Results in small-sample subgroups,and Spearman’s rank correlation analysis was applied to assess correlations between indicators. Results The positive expression rate of Ki-67 in the adenocarcinoma group was significantly higher than that in the HGIN group(P<0.05).In the HGIN subgroup with malignant tendency,the positive rates of both Ki-67 and p53 were higher than those in the subgroup without malignant tendency(P<0.05).The nature of the lesion was significantly positively correlated with Ki-67 expression,and Ki-67 expression was also significantly positively correlated with p53 expression(P<0.001). Conclusion Combined detection of Ki-67 and p53 can accurately assess the risk of malignant transformation in colorectal high-grade intraepithelial neoplasia,assist in clinical pathological differential diagnosis and individualized treatment,and has high clinical application value.
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Received: 05 April 2026
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2026, Vol. 46 
