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| Study on the Relationship Between Bone Metastasis and Serum Anti-Tartrate Acid Phosphatase,PINP,β-CTX in Patients with Breast Cancer |
| Yang Han, Tian Qing |
| Laboratory Medicine,Nanshi Hospital Affiliated to Henan University,Nanyang 473006,China |
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Abstract Objective To study the relationship between bone metastasis and serum anti-tartrate acid phosphatase（TRACP）,PINP and β-CTX levels in breast cancer patients.Methods The clinical data of 120 breast cancer patients diagnosed and treated were retrospectively analyzed.They were divided into study group（occurrence,69 cases） and control group（non-occurrence,51 cases） based on whether tumor metastasis occurred.At the same time,the patients of the study group were divided into three subgroups A,B,and C using the Soloway classification standard.The TRACP,PINP,and β-CTX levels were measured in all patients,and the relationship between the three and bone metastasis was analyzed.Results The serum levels of TRACP,PINP and β-CTX in the study group were significantly higher than those in the control group（P<0.05）;the serum levels of the patients in group C were significantly higher than those in group B and group A,and those in group B were higher than group A（P<0.05）.Serum levels of TRACP,PINP and β-CTX were positively correlated with the degree of bone metastases in breast cancer patients（P<0.05）.Conclusions erum levels of TRACP,PINP and β-CTX are positively correlated with the degree of bone metastasis in breast cancer patients,and can provide valuable reference for the diagnosis of bone metastases in breast cancer patients.
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Received: 15 December 2019
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2021, Vol. 41 
