甘麦芪仙磁石汤结合常规安眠药物对老年心脾两虚型慢性失眠患者的临床疗效以及作用机制研究

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Abstract Objective To explore the clinical efficacy and mechanism of Ganmai Qixian Magnetic Stone Decoction combined with conventional sleeping drugs in elderly patients with chronic insomnia due to heart and spleen deficiency.Methods From September 2018 to December 2019,64 elderly patients with senile insomnia who were dialectic of TCM and Spleen Deficiency were selected as the research subjects,and were divided into observation group and control group according to the random number table method.(32 cases each).The control group was given conventional sleeping medication,and the observation group was given Ganmai Qixian Magnet Decoction on the basis of the control group.The clinical efficacy and TCM symptom scores,norepinephrine(NE)and 5- Serotonin(5-HT)levels,sleep quality.Results The total effective rate of clinical efficacy in the observation group was higher than that in the control group(93.75% vs 75.00%,P<0.05),and the total effective rate of TCM symptoms was higher than the control group(93.75% vs 71.88%,P<0.05);after treatment The NE level decreased and 5-HT level increased in both groups(P<0.05).The sleep quality in both groups was improved(P<0.05),and the improvement in the observation group was better than that in the control group(P<0.05).Conclusion Ganmaiqixian Magnetic Stone Decoction combined with conventional sleep medicine can effectively improve the clinical symptoms of elderly patients with chronic insomnia with heart and spleen deficiency.The effect is more obvious than that of conventional sleep medicine alone,and its mechanism may be through affecting the brain 5- The contents of HT and NE act on the sleep-wake cycle.

Key words： Chronic insomnia Ganmai Qixian Cishi Decoction Heart and spleen deficiency type Clinical efficacy Mechanism of action

Received: 29 July 2020

PACS:

R256.23

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	Xian Zhiqiang
	Zhuang Kun
	Wen Nannan

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Xian Zhiqiang,Zhuang Kun,Wen Nannan. Study on Clinical Effect and Mechanism of Ganmaiqixian Magnetic Stone Decoction Combined with Conventional Sleeping Medicine on Elderly Patients with Chronic Insomnia[J]. journal1, 2021, 41(3): 123-125.

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http://www.hrbyybjb.org.cn/EN/ OR http://www.hrbyybjb.org.cn/EN/Y2021/V41/I3/123

[1] 樊金灼,熊健美,贺雄.养心和胃益眠汤结合针刺安眠穴治疗老年失眠的临床研究[J].中华中医药学刊,2019,37(2):466-469.
[2] 丁莉,王骏,杨澔侠,等.“督脉导气针法”联合艾司唑仑治疗失眠症:随机对照研究[J].中国针灸,2018(5):463-467.
[3] 曹文聪,海英,任路.基于数据挖掘中药复方治疗失眠用药规律分析[J].辽宁中医杂志,2018,45(9):1851-1853.
[4] 李秀娟,文彬,韩海涛,等.壮医针刺治疗心肾不交型不寐35例[J].中国针灸,2018,38(9):225-293.
[5] 孙巧杰. 酸枣仁汤加减治疗中风后失眠的临床研究[J].中医临床研究,2018,10(6):57-58.
[6] 邹品芳,周奇志,蔡定均,等.针刺调节失眠症睡眠结构和中枢神经递质的研究进展[J].中国中医基础医学杂志,2018,24(3):428.
[7] 胡树罡,沈滢,顾晓美,等.低频重复经颅磁刺激治疗老年人失眠症的疗效观察[J].中华物理医学与康复杂志,2018,40(3):187-190.
[8] 申治富,余天薇,郭保君,等.基于"阳盛瞋,阴盛瞑"跷脉理论探讨失眠与卫气的相关性[J].中华中医药杂志,2018,33(3):860-862.
[9] 王若宁. 甘草酸、甘草次酸的抗肿瘤机制及其作为药物递送载体的研究进展[J].中草药,2019,50(23):5876-5886.
[10] 王杰超,宋霄,杨爽,等.黄芪注射液治疗心脑血管病合并失眠症的作用机理[J].中国全科医学,2005,8(2):146-147.
[11] 陈建发,陈引香,朱文彬,等.沙虫酶解多糖合并参芪藿颗粒对模拟高强度训练小鼠抗疲劳作用的实验研究[J].中华航海医学与高气压医学杂志,2019,26(6):549-552.
[12] 张梓毓,徐德平.五味子助眠成分的分离鉴定[J].食品与机械,2018,34(3):167-170.
[13] 齐卓操,郭锦晨,张佩文,等.数据挖掘《王任之医案》中治疗不寐的用药规律[J].陕西中医药大学学报,2018,41(1):108-111.
[14] 周萍萍,诸毅晖,李娜,等.《幼科铁镜》人参安神汤探微[J].中国中医基础医学杂志,2018,24(8):1130-1131.
[15] 刘卫花,黄宏敏,赵光峰.补肾安神法对轻度抑郁伴焦虑失眠患者血清5-HT水平及SDS、SAS积分影响研究[J].辽宁中医杂志,2019,46(2):303-306.

[1]	. [J]. journal1, 2021, 41(5): 70-71.
[2]	. [J]. journal1, 2021, 41(5): 92-92.
[3]	. [J]. journal1, 2021, 41(5): 139-140.
[4]	. [J]. journal1, 2021, 41(4): 59-60.
[5]	. [J]. journal1, 2021, 41(4): 130-132.
[6]	. [J]. journal1, 2021, 41(3): 91-92.