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| Analysis of Clinical Value of Ultrasound Soft index in Screening Fetal Chromosomal Abnormalities in Early Pregnancy |
| Liu Qianqian |
| Nanyang Second People's Hospital,Prenatal Screening Center,Nanyang 473012,China |
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Abstract Objective To explore the clinical value of ultrasound soft index in screening fetal chromosomal abnormalities in early pregnancy. Methods 1945 pregnant women in the first trimester of pregnancy who underwent routine prenatal screening in our hospital were selected.All of them underwent ultrasound soft indicators[（fetal nasal bone（NB））,neck translucency thickness（NT）] and maternal serological examination.Amniocentesis chromosome karyotype analysis or postpartum follow-up of low-risk pregnant women were used as gold standard to analyze the value of each method. Results A total of 40 cases of fetal chromosomal abnormalities（2.06%）were detected in 1945 pregnant women in the first trimester,including 7 cases of 18 trisomy syndrome（0.36%）,19 cases of 21 trisomy syndrome（0.98%）,4 cases of 45x（0.21%）,5 cases of 13 trisomy syndrome（0.26%）,2 cases of chromosome segment abnormality（0.10%）,3 cases of triploidy（0.15%）;126 cases of NT abnormalities（6.48%）,1819 cases of normal NT（93.52%）;12 cases of NB deletion（0.62%）,1932 cases of normal NB（99.33%）,amniocentesis showed 28 cases（1.44%）of fetal chromosomal abnormalities;111 cases（5.71%）of high-risk pregnant women were screened by serology,Amniocentesis showed 31 cases（1.59%）of fetal chromosomal abnormalities;the detection rate of fetal chromosomal abnormalities by ultrasound soft index combined with serological examination was higher than that by ultrasound soft index and serological single examination,the difference was statistically significant（P<0.05）;There was no significant difference in the detection rate of fetal chromosomal abnormalities between ultrasound soft index and serology（P>0.05）. Conclusion Ultrasound soft index can effectively detect fetal chromosomal abnormalities in early pregnancy,which combined with serological examination can improve the detection rate of fetal chromosomal abnormalities and improve the quality of the birth population.
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Received: 05 September 2020
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2021, Vol. 41 
