血清cathepsin S、ANGPTL3、HN水平与冠心病患者病情程度及预后的相关性分析

doi:10.3969/j.issn.1001-8131.2024.04.013

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (628 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the correlation between serum levels of cathepsin S,angiopoietin-like protein 3（ANGPTL3）and anti-apoptotic polypeptide（HN）and their predictive value in patients with coronary heart disease and the severity of the disease.Methods A total of 126 patients with coronary heart disease who underwent percutaneous coronary intervention（PCI）were selected as the study group,and were divided into 45 cases of single lesions,42 cases of double lesions,and 39 cases of multiple lesions according to the number of lesions,and 42 patients with healthy examination in the same period were selected as the control group.The serum levels of cathepsin S,ANGPTL3 and HN were compared between the two groups.The serum levels of cathepsin S,ANGPTL3,HN and Gensini score were compared in the study group.The correlation between serum levels of cathepsin S,ANGPTL3 and HN and the number of lesions and Gensini score was analyzed.According to the prognosis of the study group within 6 months after treatment,the patients with poor prognosis and those with good prognosis were divided,and the serum levels of cathepsin S,ANGPTL3 and HN were compared.Multivariate logistic regression was used to analyze the influencing factors of poor prognosis,and receiver operating characteristic curve（ROC）was used to analyze the predictive value of individual and combined serum indexes for poor prognosis.Results The serum levels of cathepsin S and ANGPTL3 in the study group were higher than those in the control group,and the levels of HN were lower than those in the control group（P<0.05 ANGPTL3<ANGPTL3）.On the contrary,HN（P<0.05）,the serum levels of cathepsin S and ANGPTL3 in patients with poor prognosis were higher than those with good prognosis at 1 month after treatment,and the levels of HN were lower than those with good prognosis（P<0.05 ANGPTL3）.LVEF and serum HN level at 1 month after treatment were independent protective factors for poor prognosis（P<0.05）,and the AUC of cathepsin S,ANGPTL3 and HN was greater than that predicted by individual indicators（P<0.05）.Conclusion The serum levels of cathepsin S and ANGPTL3 are increased,while the serum HN level is decreased,which is closely related to the severity and prognosis of the disease.

Key words： Coronary heart disease Cathepsin S Angiopoietin-like protein 3 Anti-apoptotic peptides Prognosis Forecast

Received: 14 March 2024

PACS:

R541.4

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Li Junfeng
	Yang Sen
	Gao Qiang

Cite this article:

Li Junfeng,Yang Sen,Gao Qiang. Correlation analysis of serum cathepsin S,ANGPTL3 and HN levels with the severity and prognosis of patients with coronary heart disease[J]. journal1, 2024, 44(4): 44-47.

URL:

http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2024.04.013 OR http://www.hrbyybjb.org.cn/EN/Y2024/V44/I4/44

[1] TAO S Y,TANG X W,YU L T,et al.Prognosis of coronary heart disease after percutaneous coronary intervention:a bibliometric analysis over the period 2004-2022[J].Eur J Med Res,2023,28(1):311-321.
[2] 马婷婷,邱晓平,张立新.糖尿病合并冠心病患者血浆组织蛋白酶S和血小板反应蛋白-1浓度与心力衰竭的关系[J].岭南心血管病杂志,2020,26(1):48-51.
[3] 陈丽芳,黄于朗,柯晓.血清软骨糖蛋白39和血管生成素样蛋白3水平与老年冠心病心力衰竭患者左心室功能不全的相关性[J].中华老年医学杂志,2021,40(9):1107-1111.
[4] HAZAFA A,BATOOL A,AHAMD S,et al.Humanin:A mitochondrial-derived peptide in the treatment of apoptosis-related diseases[J].Life Sci,2021,264(1):118679-118689.
[5] 中国心血管病预防指南(2017)写作组,中华心血管病杂志编辑委员会.中国心血管病预防指南(2017)[J].中华心血管病杂志,2018,46(1):10-25.
[6] 雷肖蠢,倪宁,李鑫,等.冠心病患者血清HN、CTRP3与血脂及病情严重程度的关系研究[J].现代生物医学进展,2020,20(21):4134-4138.
[7] 尹锐,贾国渠,陈巍,等.冠心病患者PCI术后血清IL-33、sST2、LP-PLA2水平及其与预后的关系[J].标记免疫分析与临床,2021,28(3):457-461.
[8] 董昭杰,徐西子,李广平.单核细胞/高密度脂蛋白胆固醇比值与冠状动脉Gensini评分的关系[J].天津医科大学学报,2017,23(2):157-160.
[9] LIU Y H,ZHU B B,ZHOU W C,et al.Triglyceride-glucose index as a marker of adverse cardiovascular prognosis in patients with coronary heart disease and hypertension[J].Cardiovasc Diabetol,2023,22(1):133-143.
[10] 翟兰芳,李得娟.血清ALP,musclin,cathepsin S水平与冠心病疾病严重程度的关系[J].中南医学科学杂志,2022,50(1):117-120.
[11] 罗庭,周小雁,罗平,等.急性冠脉综合征患者血清ANGPTL3与炎症激活、糖脂代谢紊乱的相关性研究[J].中国循证心血管医学杂志,2020,12(10):1251-1254.
[12] 路亚丽,周艳芳,杜慧娟,等.冠心病患者血清抗凋亡多肽,白细胞介素-33,高敏心肌肌钙蛋白,乳酸脱氢酶与病情严重程度相关性研究[J].华南预防医学,2023,49(4):500-506.
[13] 魏亚倩,陈兴龙,张璐.冠心病患者血清RPs、RBP4、HN水平与冠状动脉病变程度的关系[J].海南医学,2023,34(16):2295-2300.