塞来昔布预给药+腰丛神经阻滞复合全身麻醉对髋关节置换术患者术后疼痛、炎症因子及关节功能恢复的影响

doi:10.3969/j.issn.1001-8131.2025.02.012

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Abstract Objective To investigate the effects of pre-administration of celecoxib combined with lumbar plexus block and general anesthesia on postoperative pain,inflammatory factors,and joint function recovery in patients undergoing hip replacement surgery.Methods A total of 86 patients admitted to the hospital for hip replacement surgery were randomly divided into an observation group（n=43）and a control group（n=43）.Both groups received lumbar plexus block combined with general anesthesia,followed by patient-controlled intravenous analgesia（PCIA）postoperatively.Additionally,the observation group took oral celecoxib 8 hours before anesthesia induction.Pain levels at rest and during activity at different time points postoperatively,as well as serum levels of inflammatory and pain factors,were compared.The time to first straight leg raise,hip flexion to 90°,and the maximum flexion and abduction range of the affected hip joint postoperatively were recorded.Postoperative recovery and perioperative adverse events were also documented.Results The Visual Analog Scale（VAS）scores at rest and during activity at 6,12,24,and 48 hours postoperatively were significantly lower in the observation group than in the control group（P<0.05）.Serum levels of tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）,prostaglandin E2（PGE2）,and β-endorphin（β-EP）at 24 and 48 hours postoperatively were significantly lower in the observation group than in the control group（P<0.05）.The time to first straight leg raise and hip flexion to 90° was significantly shorter in the observation group,and the maximum flexion and abduction range of the affected hip joint at 24 and 48 hours postoperatively were significantly greater than those in the control group（P<0.05）.The recovery time,extubation time,and time to ambulate were significantly shorter in the observation group,and the number of PCIA compressions within 48 hours postoperatively was significantly lower than that in the control group（P<0.05）.The incidence of postoperative delirium and the total incidence of perioperative adverse events were significantly lower in the observation group than in the control group（P<0.05）.Conclusion The combination of celecoxib and lumbar plexus block effectively enhances postoperative analgesia,reduces levels of inflammatory and pain factors,promotes hip joint function recovery,and decreases the incidence of postoperative delirium in patients undergoing hip replacement surgery,warranting its promotion.

Key words： Hip replacement Celecoxib Lumbar plexus block Analgesia Inflammatory factors Joint function

Received: 18 February 2025

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Liu Xianting. Effects of Celecoxib Preadministration Plus Lumbar Plexus Block Combined with General Anesthesia and Lumbar Plexus Block on Postoperative Pain,Inflammatory Factors and Joint Function Recovery in Patients with Hip Replacement[J]. journal1, 2025, 45(2): 40-43.

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http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2025.02.012 OR http://www.hrbyybjb.org.cn/EN/Y2025/V45/I2/40

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