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| Diagnostic Value and Prognostic Evaluation Ability of Real-Time Elastography and FibroScan in Evaluation of Liver Fibrosis About Non-Alcoholic Fatty Liver Disease Patients |
| Lei Lisha1, Xi Yunzhu2, Yan Canqun1, Luo Jing1, Tan Wei1 |
1. Hengyang Medical College of Nanhua <Health Management Center of The Second Affiliated Hospital of Nanhua University>,Hengyang 421001,China;
2. Hengyang Medical College of Nanhua<Department of Respiratory and Critical Care Medicine,The Second Affiliated Hospital of Nanhua University>,Hengyang 421001,China |
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Abstract Objective Observe the effect of diagnosis and evaluation of the effect after treatment of real-time elastography and FibroScan in evaluation of liver fibrosis about Non-alcoholic fatty liver disease patients. Methods Selected 241 NAFLD patients admitted as the research objects.Among them,136 patients with liver fibrosis were in the observation group,and 105 patients without liver fibrosis were in the control group.Both groups were given FS and RTE examinations,and the differences in general information and examination results of the two groups were compared.Observe and compare the results of FS and RTE examinations of the two groups of patients,and judge the diagnostic efficacy of the two detection methods and their combined use.Patients in the observation group were treated with anti-hepatic fibrosis drugs for 6 months to observe the treatment effect and the changes in laboratory indicators,FS and RTE examination results before and after treatment,and judge its effectiveness in prognostic evaluation. Results The ALT,AST,TC,and TG of the observation group of laboratory indicators were all higher than those of the control group（P<0.05）,and the differences were statistically significant.The LFI value of the observation group before treatment was 3.82±1.42 on average,which was higher than the control group 2.78±0.83 The difference was statistically significant（t=39.652,P<0.05）.The average LSM value of the observation group was 19.52±2.98,which was higher than that of the control group by 5.51±1.11.The difference was statistically significant（t=59.672,P<0.05）.The LFI value,LSM value and the ROC curve parameter area of the combined diagnosis are all higher than 0.700,indicating that the two indicators have higher diagnostic efficiency,but the sensitivity and specificity of the combination of the two are higher than the diagnosis result of a single indicator（P<0.05）.After the observation group was treated with anti-liver fibrosis drugs for 6 consecutive months,the laboratory indexes,LFI and LSM values all decreased significantly（P<0.05）. Conclusion Both FS and RTE are of high value in the diagnosis of liver fibrosis in patients with NAFLD.They can accurately determine the degree of liver fibrosis,simple operation,high accuracy,and strong repeatability.They can be used as anti-fibrosis treatments for patients As a non-invasive detection method for prognostic evaluation,it is recommended that the two be combined to further improve the accuracy of diagnosis.
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Received: 20 May 2021
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2021, Vol. 41 
