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| Correlation Between Serum Lp（a）,APN Levels and Renal Injury in Patients With Diabetic Nephropathy |
| Wang Li |
| Laboratory of Zhoukou First People's Hospital,Zhoukou 466700,China |
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Abstract Objective To investigate the correlation between serum lipoprotein（a）,LP（a）,adiponectin（APN）levels and renal injury in patients with diabetic nephropathy（DN）. Methods The clinical data of 60 patients with DN admitted were collected and included in group A,and the clinical data of 60 patients with simple type 2 diabetes mellitus（T2DM）admitted to the hospital during the same period were collected and included in group B.The general data of patients and laboratory indexes [Lp（a）,APN] were collected,and the correlation between Lp（a）,APN levels and renal injury in patients with DN was analyzed. Results In group A,there were 0 cases in stage I,0 cases in stage II,52 cases in stage III,8 cases in stage IV and 0 cases in stage v.The level of serum Lp（a）in patients with stage IV was higher than that in patients with stage III and group B,and the level of serum APN in patients with stage III was lower than that in patients with stage III and group B,and the difference was statistically significant（P<0.05）;Pearson linear correlation analysis showed that serum Lp（a）was positively correlated with renal injury index（UAER）in patients with DN（r>0,P<0.001）;APN was negatively correlated with UAER（r<0,P<0.001）. Conclusion Serum Lp（a）and APN levels are associated with renal injury in patients with DN.The occurrence and development of renal injury in patients with DN can be evaluated by monitoring serum Lp（a）and APN levels.
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Received: 04 December 2020
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2021, Vol. 41 
