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| The Expression and Clinical Significance of Serum PC,hs-CRP and NT-proBNP in Different Coronary Artery Diseases of Coronary Heart Disease |
| Yang Fan, Sun Jun, Yang Dongbo |
| The Seventh People's Hospital of Zhengzhou,Zhengzhou 450000,Henan,China |
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Abstract Objective To investigate the expression and clinical significance of serum plasma protein C（PC）,highly sensitive C-reactive protein（hs-CRP）and amino-terminal B-type brain natriuretic peptide（NT-proBNP）in coronary heart disease（CHD）and coronary artery disease. Methods 80 cases of CHD patients and 80 cases of healthy people who underwent physical examination were selected as observation group and control group .According to clinical classification,CHD was divided into stable angina pectoris group（n=24）,unstable angina pectoris group（n=31）and myocardial infarction group（n=25）.Serum levels of PC,hs-CRP and NT-proBNP were detected in all patients.Coronary angiography was carried out in the observation group,and the patients were divided into single-branch lesion group（n=22）,double-branch lesion group（n=34）and multi-branch lesion group（n=24）according to the number of coronary lesions.The levels of serum PC,hs-CRP and NT-proBNP in control group and observation group,different clinical types（stable angina pectoris group,unstable angina pectoris group,myocardial infarction group）and different coronary lesions（single-branch disease group,double-branch disease group,multi-branch disease group）were compared.A risk assessment model was established,and the diagnostic efficacy of serum PC,hs-CRP and NT-proBNP in detecting myocardial infarction was evaluated by receiver operating characteristic curve（ROC）. Results Compared with the control group,the level of serum PC in the observation group was lower,the level of hs-CRP and NT-proBNP was higher（P<0.05）.Compared with unstable angina group and myocardial infarction group,the level of serum PC in stable angina group was higher,and the level of hs-CRP and NT-proBNP was lower（P<0.05）.The level of serum PC in multi-branch disease group was significantly lower than that in single-branch disease group and double-branch disease group,and the level of hs-CRP and NT-proBNP in multi-branch disease group was higher（P<0.05）.According to ROC curve analysis,the combined detection of serum PC,hs-CRP and NT-proBNP in the established risk assessment model had the highest AUC value,which was 0.958,and the sensitivity and specificity were 96.00% and 84.00%. Conclusion The more severe the coronary lesions in CHD patients,the lower the serum level of PC,hs-CRP,NT-proBNP levels.The serum levels of PC,hs-CRP and NT-proBNP have certain clinical value in the evaluation of different degrees of coronary lesions of CHD.The combined detection of serum PC,hs-CRP and NT-proBNP has high diagnostic efficacy in the diagnosis of coronary heart disease myocardial infarction.
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Received: 17 April 2023
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[1] 周龙,林岚,陈蓉,等.急性冠状动脉综合征患者血清NT-proBNP、Hcy及hs-CRP水平变化及临床意义分析[J].国际检验医学杂志,2018,39(13):1625-1628.
[2] 闫葱珊,王县委.血清PC、hs-CRP及NT-proBNP在冠心病不同冠脉病变中的表达及临床意义[J].辽宁医学杂志,2022,36(1):73-75.
[3] 李凌,孟媛媛.Lp-PLA2、D-二聚体和hs-CRP与冠心病患者冠状动脉病变程度的相关性[J].检验医学与临床,2021,18(4):476-478.
[4] 段亚妮,张军,解建毅.早发冠心病患者心脏标志物四项、PCT、BNP水平的变化及临床意义[J].海南医学,2021,32(20):2626-2630.
[5] 孙春喜,任小鹏,李建成,等.冠心病患者hs-CRP、DPP-4水平及其与冠状动脉病变程度的相关性[J].海南医学,2020,31(11):1397-1400.
[6] 王晓玲,张立杰,肖四海,等.冠心病患者血清NT-proBNP、尿酸和hs-CRP水平与冠状动脉病变的关系[J].疑难病杂志,2019,18(3):217-219,242.
[7] 陈岗,康妮娜.冠心病患者血清PAPP-A、PC、hs-CRP水平与冠脉病变程度及预后的相关性研究[J].标记免疫分析与临床,2020,27(3):432-435.
[8] 张朝华,刘旭帮,汤建民.冠心病患者血清超敏C反应蛋白、同型半胱氨酸和胱抑素C的水平及临床意义[J].医药论坛杂志,2021,42(2):71-74.
[9] 陈小燕. 血清脑钠肽N末端前体蛋白及CA125检查在评估冠心病心力衰竭中的临床意义[J].基层医学论坛,2022,26(22):65-67.
[10] 程航,夏敏.冠心病患者血清DKK-1、microRNA-181b、cTnI水平与冠脉病变程度的关系[J].武汉大学学报(医学版),2020,41(3):468-471.
[11] 史菲,龙森,张娜,等.血清同型半胱氨酸、叶酸、维生素B12水平与冠心病患者冠状动脉病变程度的相关性[J].中国老年学杂志,2020,40(21):4484-4486. |
| [1] |
Wang Dongdong, Chen Zhaojin. The Relationship between Serum Lp（a）Level and The Degree of Coronary Artery Disease in Patients with Coronary Heart Disease and T2DM[J]. journal1, 2024, 44(2): 24-27. |
| [2] |
Hou Bin, Zheng Fangfang. Clinical Value of Atorvastatin Calcium Combined with Fenofibrate in the Treatment of Coronary Atherosclerotic Heart Disease[J]. journal1, 2024, 44(1): 11-14. |
| [3] |
. [J]. journal1, 2023, 43(5): 63-64. |
| [4] |
. [J]. journal1, 2023, 43(4): 65-66. |
| [5] |
. [J]. journal1, 2023, 43(3): 105-107. |
| [6] |
Du Juan. Application of High Frequency Electrocardiogram Combined With Exercise Stress Electrocardiogram in the Diagnosis of Occult Coronary Heart Disease[J]. journal1, 2022, 42(5): 39-41. |
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2024, Vol. 44 
