外周血NLR、PLR水平与初诊多发性骨髓瘤患者预后的关系探讨

doi:10.3969/j.issn.1001-8131.2024.02.005

Abstract
Figure/Table
References
Related Citation (3)

Download: PDF (660 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the relationship between peripheral blood neutrophil to lymphocyte count ratio（NLR）and platelet to lymphocyte count ratio（PLR）and prognosis of newly diagnosed multiple myeloma（MM）patients. Methods The general data of 86 newly diagnosed MM patients wereretrospectively analyzed.General data（gender,age,ISS stage）of the patients were collected,and the levels of granulocyte count,lymphocyte count,platelet count,Hb,ALB,Cr,Ca,β2 microglobulin were detected,and NLR and PLR were calculated.According to the levels of NLR and PLR,patients were divided into high NLR group（NLR≥2.54,n=32）,low NLR group（NLR<2.54,n=54）,high PLR group（PLR≥135,n=41）and low PLR group（PLR<135,n=45）.Kaplan-Meier curve was used to determine the overall survival time（OS）of patients,and Log-Rank test was performed to analyze the survival of patients with different NLR and PLR levels.A risk assessment model was established,and the diagnostic efficacy of NLR and PLR in evaluating the prognosis of newly diagnosed MM patients was analyzed by receiver operating characteristic curve（ROC）. Results The levels of ISS staging,Ca,Cr and β2 microglobulin between high NLR group and low NLR groupwere significant differences（P<0.05）.There were significant differences in ISS stage,Cr and β2 microglobulin levels between high PLR group and low PLR group（P<0.05）.The survival time of high NLR group was（13.28±1.99）months,and that of low NLR group was（36.15±5.42）months.The survival time of high NLR group was shorter than that of low NLR group（χ²=13.984,P=0.000<0.05）.The survival time of high PLR group was（25.31±3.79）months,and that of low PLR group was（33.26±4.98）months.The survival time of high PLR group was shorter than that of low PLR group（χ²=8.767,P=0.003<0.05）.Based on the ROC curve analysis the AUC value of NLR and PLR combined detection mode was the highest,which was 0.923,and the sensitivity was 92.85%、the specificity was 85.71%. Conclusion The levels of NLR and PLR in peripheral blood are closely related to the prognosis of newly diagnosed MM patients.The levels of NLR and PLR in patients with MM were negatively correlated with the prognosis and survival time.At the same time,the combined detection of NLR and PLR has high clinical value in evaluating the prognosis of newly diagnosed MM patients.

Key words： multiple myeloma First visit Neutrophil to lymphocyte count ratio Platelet to lymphocyte count ratio

Received: 20 April 2023

PACS:

R738.1

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Chen Yi
	Zheng Ximing
	Zhang Airong

Cite this article:

Chen Yi,Zheng Ximing,Zhang Airong. Relationship between Peripheral Blood NLR,PLR and Prognosis of Newly Diagnosed Multiple Myeloma Patients[J]. journal1, 2024, 44(2): 14-17.

URL:

http://www.hrbyybjb.org.cn/EN/10.3969/j.issn.1001-8131.2024.02.005 OR http://www.hrbyybjb.org.cn/EN/Y2024/V44/I2/14

[1] 孙真真,许德英,王小利,等.外周血中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对初诊多发性骨髓瘤患者总生存情况的预测价值[J].中国慢性病预防与控制,2020,28(3):213-217.
[2] 崔壮壮,张媛媛,金北平,等.中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对初诊多发性骨髓瘤患者总生存和无进展生存的预测意义[J].解放军医学院学报,2019,40(2):121-126.
[3] 宫文玉,金其川,鲍文强.多发性骨髓瘤患者RDW及PLR与预后的关系[J].湖南师范大学学报(医学版),2022,19(2):187-191.
[4] 中国医师协会血液科医师分会,中华医学会血液学分会,中国医师协会多发性骨髓瘤专业委员会.中国多发性骨髓瘤诊治指南(2017年修订)[J].中华内科杂志,2017,56(11):866-870.
[5] Szudy-Szczyrek A,mLak R,Mielnik M,et al.Prognostic value of pretreatment neutrophil-to-lymphocytePrognostic value of pretreatment neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in multiple myeloma patients treated with thalidomide-based regimen[J].Ann Hematol.2020 Dec;99(12):2881-2891.
[6] 刘红春,黄国虹,崔彦杰,等.中性粒细胞/淋巴细胞比值对多发性骨髓瘤患者的预后评估价值[J].国际检验医学杂志,2020,41(10):1203-1205,1209.
[7] 巢玲,谢璟,徐烨,等.中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值对三药联合方案初始治疗多发性骨髓瘤患者无进展生存时间的预测价值[J].中国当代医药,2022,29(20):156-160.
[8] 苏传勇,陶叠宏,任莉,等.多发性骨髓瘤患者外周血NLR水平与T淋巴细胞亚群的相关性及对预后的影响[J].中华全科医学,2022,20(2):209-211,232.
[9] Sweiss K,Lee J,Mahmud N,et al.Combined immune score of lymphocyte to monocyte ratioCombined immune score of lymphocyte to monocyte ratio and immunoglobulin levels predicts treatment-free survival of multiple myeloma patients after autologous stem cell transplant[J].Bone Marrow Transplant.2020 Jan;55(1):199-206.
[10] 许德英,孙真真,王小利,等.初诊中性粒细胞与淋巴细胞比值、淋巴细胞亚群及免疫分型对多发性骨髓瘤患者总生存时间的影响[J].中国实验诊断学,2020,24(5):722-726.
[11] 张琪,甘宜敏,徐阳,等.多发性骨髓瘤患者NLR、β2-MG、LDH与免疫表型、细胞遗传学及预后生存的关系[J].国际检验医学杂志,2022,43(13):1648-1652.
[12] Ramasamy K,Dhanasiri S,Thom H,et al.Relative efficacy of treatment options in transplant-ineligible newly diagnosed multiple myeloma:results from a systematic literature reviewRelative efficacy of treatment options in transplant-ineligible newly diagnosed multiple myeloma:results from a systematic literature review and network meta-analysis[J].Leuk Lymphoma.2020 Mar;61(3):668-679.
[13] 贾淑青. 多发性骨髓瘤患者预后的相关影响因素分析[J].实用癌症杂志,2022,37(4):605-607.
[14] 石巧梅,朱宏,齐铭,等.基于炎症指数的评分系统作为初诊多发性骨髓瘤患者预后标志的研究[J].临床血液学杂志,2021,34(7):458-467.
[15] 安然,陈钰,张苏江,等.免疫炎性指标和淋巴细胞亚群在初诊多发性骨髓瘤预后判断中的意义[J].临床血液学杂志,2022,35(3):168-173.
[16] Solmaz Medeni S,Acar C,Olgun A,et al.Can Neutrophil-to-Lymphocyte RatioCan Neutrophil-to-Lymphocyte Ratio,Monocyte-to-Lymphocyte Ratio,and Platelet-to-Lymphocyte Ratio at Day +100 be used as a prognostic marker in Multiple Myeloma patients with autologous transplantation[J].Clin Transplant.2018 Sep;32(9):e13359.