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| The Predictive Value of Serum ALT,AST,and Immunoglobulin Levels for the Severity of Hepatitis B in Patients |
| Huang Chenlu1, Huang Xinyi2 |
1. Shangrao Health School Affiliated Hospital,Shangrao,Jiangxi,334600;
2. Hengshan Branch of Guangfeng District General Hospital,Shangrao City,Jiangxi Province,334600 |
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Abstract Objective To explore the predictive value of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),and immunoglobulin levels on the severity of hepatitis B(HB)in patients. Method 127 patients with HB were selected.The severity of the patients' condition was evaluated according to relevant standards,and serum ALT,AST,and immunoglobulin levels were detected and compared among patients with different severity levels.ALT,AST,and immunoglobulin levels were analyzed AST,The relationship and predictive value between immunoglobulin levels and the severity of HB patients. Result Among the 127 patients with HB,38 cases(29.92%)were mild,59 cases(46.46%)were moderate,and 30 cases(23.62%)were severe;Severe HB patients with ALT AST,The levels of immunoglobulin A(IgA),immunoglobulin M(IgM),and immunoglobulin G(IgG)were higher in moderate and mild patients,respectively(P<0.05);Kendall's tau-b correlation coefficient test showed that the levels of ALT,AST,IgA,IgM,and IgG were positively correlated with the severity of HB patients(r>0,P<0.05);Plotting ROC curves shows that the AUC of predicting moderate to severe illness in HB patients by detecting ALT,AST,IgA,IgM,and IgG separately or by combining various indicators is all greater than 0.70,indicating diagnostic value,with the highest value observed in combined detection. Conclusion Serum ALT AST、 The level of immunoglobulin is related to the severity of HB patients' condition and has high predictive value for the severity of HB patients' condition.It is considered to be one of the auxiliary indicators for judging the severity of patients' condition in the future.
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Received: 20 February 2025
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2025, Vol. 45 
